Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore
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SciScore for 10.1101/2020.09.14.20186494: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics approval was obtained from SingHealth Centralized Institutional Review Board (CIRB Ref No: 2020/2537).
Consent: All patients provided informed consent upon recruitment in the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Hence, despite limitations, the present study …
SciScore for 10.1101/2020.09.14.20186494: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics approval was obtained from SingHealth Centralized Institutional Review Board (CIRB Ref No: 2020/2537).
Consent: All patients provided informed consent upon recruitment in the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Hence, despite limitations, the present study will provide a novel insight on this important topic, particularly at the time of the current COVID-19 pandemic. It is noteworthy that anti-septic mouth-rinses should not be regarded as a treatment for SARS-CoV-2. Nevertheless, mouth-rinses could play a vital role in minimizing the spread of SARS-CoV-2 with its use as a pre-procedural strategy in dental clinics (Vergara-Buenaventura and Castro-Ruiz 2020). This is especially important as significant amounts of aerosols are generated in a relatively closed setting during dental treatments (Ge and others 2020). Health authorities such as, Centre for Disease Control and Prevention (CDC) and Australian Dental Association (ADA) have recommended the use of pre-procedural mouth-rinses for dental treatment, even without robust clinical evidence (ADA 2020; CDC 2020). Therefore, the present study provides the much-needed evidence on the efficacy of commercial mouth-rinses for salivary SARS-CoV-2 viral load in a group of COVID-19 positive patients in Singapore. It was observed that CPC and PI mouth-rinses have sustained effect in reducing viral load in saliva compared to water control in our study. Previously, CPC has been shown to have anti-viral activity against influenza viruses in in vitro with an EC50 of 5–20 ug/ml and in vivo, through direct attack on the viral envelope (Popkin and others 2017). The virucidal spectrum of PI has been reported to be against both enveloped and non-envelope...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title ISRCTN95933274 NA NA Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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