Endotracheal Application of Ultraviolet A Light in Critically Ill Patients with Severe Acute Respiratory Syndrome Coronavirus 2: A First-in-Human Study
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2021.03.05.21252997: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: ClinicalTrials.gov number NCT04572399) was approved by the institutional review board of Cedars-Sinai, Los Angeles and was overseen by an independent data and safety monitoring board (DSMB).
Consent: Subjects’ legally authorized representatives provided written informed consent.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Pregnant women were excluded. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected …SciScore for 10.1101/2021.03.05.21252997: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: ClinicalTrials.gov number NCT04572399) was approved by the institutional review board of Cedars-Sinai, Los Angeles and was overseen by an independent data and safety monitoring board (DSMB).
Consent: Subjects’ legally authorized representatives provided written informed consent.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Pregnant women were excluded. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:While externally applied UV therapy is commonly used in dermatologic diseases, due to technological limitations and knowledge gaps, internal UV therapy has never previously been performed. In this first-in-human study, endotracheal UVA light appeared safe in critically ill patients with COVID-19. Furthermore, a significant reduction in endotracheal SARS-CoV-2 levels was observed following 5 days of UVA therapy. Finally, the reduction of viral load during UVA treatment correlated with the reduction in the WHO clinical severity scores. Apart from a dysregulated inflammatory response, heightened viral replication has a critical role in pathogenesis of severe and critical COVID-19. There is a significant association between respiratory SARS-CoV-2 load and mortality.[12] In addition, severe cases of COVID-19 exhibit longer duration and a later peak of virus in respiratory samples as compared to mild disease.[13] Aligned with these findings, 4 out of 5 of our subjects had high viral loads in the endotracheal aspirate at baseline ICU care without a significant correlation with the time of symptom onset. In addition, improvement of WHO clinical severity scores by day 30 significantly correlated with the reduction of viral load during UVA therapy. Taken together, these suggest a temporal overlap between the viral replication and hyperinflammatory phases[2] in the disease course of critically ill COVID-19 patients. Hence, these patients may continue to benefit both from viral load redu...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04572399 Completed UVA Light Device to Treat COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
-
