Exertional hypoxia in patients without resting hypoxia is an early predictor of moderate to severe COVID-19
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
-
SciScore for 10.1101/2020.12.14.20248209: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was approved by the Northwestern University Institutional Review Board. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First our study was performed at one health network with a relatively small number of patients potentially limiting …
SciScore for 10.1101/2020.12.14.20248209: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was approved by the Northwestern University Institutional Review Board. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First our study was performed at one health network with a relatively small number of patients potentially limiting generalizability. However, the associations between ambulatory hypoxia and worsening oxygenation were statistically very strong. Second, we excluded patients who did not have ambulatory oximetry measurements. Ambulatory oxygen measurement is part of the admission order protocols in our health system, so patients without measurements likely represented a sicker cohort unable to ambulate or those discharged quickly. Patients without measurement may also have been cared for by clinicians who did not order ambulatory oximetry, given lacking evidence. Third, we did not directly measure the presence of resting hypoxia because it was often not documented in the medical record before the use of oxygen therapy. The use of oxygen therapy was used as a surrogate for resting hypoxia. Finally, we excluded all patients who used oxygen therapy before ambulatory oximetry measures. These patients likely underwent ambulatory oximetry to determine discharge readiness. Alternatively, there may have been a small number of these patients who were given NC treatment for subjective comfort without resting hypoxia, who then developed ambulatory hypoxia. Future randomized studies should be performed to evaluate earlier interventions in patients with COVID-19 and ambulatory hypoxia without resting hypoxia. An important extension of our findings could be ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-