Self-reported Taste and Smell Disorders in Patients with COVID-19: Distinct Features in China

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Abstract

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  1. SciScore for 10.1101/2020.06.12.20128298: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The study was approved by Tongji Hospital Research Ethics Committee.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    These statistical analyses were performed by using an IBM SPSS 22.0 package (SPSS Inc, Chicago, IL).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    In order to overcome this limitation in real-world setting, we did recalled questionnaires by phone call to reevaluate the presence of airway comorbidities, and frequency and severity of nasal symptoms. As a result, the frequencies of COVID-19 patients with AR and CRS were 9.8% and 6.1%, respectively. Previous studies have reported that adult AR and CRS in general population in China were 17.6% and 8%, respectively, these being higher than the reported for COVID-19 [24, 25]. Recent studies indicate that the increasing eosinophils may be an indicator of COVID-19 improvement [26, 27]. Hence, we cannot rule out the possibility that the comorbidities of allergic and eosinophilic diseases such as AR might be potential protective factors for severe COVID-19. Here, we found that upper respiratory tract symptoms were identified in 29.2% patients with COVID-19, with nasal obstruction, rhinorrhea, nasal itching and sneezing presenting in mild/moderate severity and loss of smell and taste presenting in moderate/severe severity. All of these upper respiratory tract symptoms have been commonly reported in other respiratory viral infection, such as influenza and rhinovirus [28-30]. Our data suggest that similar with the common respiratory virtues, SARS-CoV-2 may be able to infect upper respiratory tract mucosa and cause similar symptoms [22, 29, 31]. In addition, the result in our Wuhan cohort revealed that the self-reported symptoms of upper respiratory tract were not the first symptom in...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.