When might host heterogeneity drive the evolution of asymptomatic, pandemic coronaviruses?
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SciScore for 10.1101/2020.12.19.20248566: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:By design, but also due to limitations in the data, our numerical analyses surveyed a wide segment of parameter space. Given the frequency with which a more asymptomatic coronavirus emerged and spread in our simulations, as well as the distinct qualitative outcomes of the role of isolation and quarantine efforts, we highlight the need for better measurements of key quantities. A case in point is the degree to which mutations enable viruses to …
SciScore for 10.1101/2020.12.19.20248566: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:By design, but also due to limitations in the data, our numerical analyses surveyed a wide segment of parameter space. Given the frequency with which a more asymptomatic coronavirus emerged and spread in our simulations, as well as the distinct qualitative outcomes of the role of isolation and quarantine efforts, we highlight the need for better measurements of key quantities. A case in point is the degree to which mutations enable viruses to cause asymptomatic infections. Because selection against symptomatic strains involves a reciprocal interplay between epidemiological and evolutionary processes, the evolution and spread of the novel strain at times depended on the probability that infection with the novel virus is asymptomatic. Thus, any intervention measure aimed at preventing the emergence of an asymptomatic strain must take into account the viral genotype-phenotype map. To be sure, whether a virus causes symptoms also depends heavily on the host’s biology. Nevertheless, in light of our results, given the growing capacity to characterize large amounts of viral sequence variation, explaining how this variability drives the propensity of viral infections to be symptomatic (such as Korber et al. 2020) seems particularly warranted. In conclusion, our analyses show how the evolution and spread of asymptomatic viruses is driven by a reciprocal interplay between public health intervention measures and prevailing host population structure, on the one hand, and the nature of th...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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