Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19
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SciScore for 10.1101/2020.09.29.20203869: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization Studies were eligible for inclusion if they were randomized clinical trials comparing hydroxychloroquine as prophylaxis (pre-exposure or post-exposure) for COVID-19 with a non-active control, included individuals who were PCR-negative at the time of treatment assignment, had been completed, and had the full text published in a peer-reviewed journal or as a pre-print. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Given the relatively small number of trials conducted so far, we identified candidate studies through expert consultation and … SciScore for 10.1101/2020.09.29.20203869: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization Studies were eligible for inclusion if they were randomized clinical trials comparing hydroxychloroquine as prophylaxis (pre-exposure or post-exposure) for COVID-19 with a non-active control, included individuals who were PCR-negative at the time of treatment assignment, had been completed, and had the full text published in a peer-reviewed journal or as a pre-print. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Given the relatively small number of trials conducted so far, we identified candidate studies through expert consultation and confirmed the findings with a search of PubMed and medRxiv as of January 2, 2021, using the search strategy in the Appendix. PubMedsuggested: (PubMed, RRID:SCR_004846)The risk of bias of the included studies was assessed independently by 2 authors (XGA, MAH) using the “Rob 2” tool by the Cochrane Bias Methods Group (7). Cochrane Biassuggested: (Robot Reviewer, RRID:SCR_018961)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.09.29.20203869: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04359537 Recruiting Efficacy of … SciScore for 10.1101/2020.09.29.20203869: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04359537 Recruiting Efficacy of Various Doses of Hydroxychloroquine in Pre-Expos... NCT04352946 Not yet recruiting HEalth Care Worker pROphylaxis Against COVID-19: The HERO Tr... NCT04374942 Enrolling by invitation Does Hydroxychloroquine Before & During Patient Exposure Pro... NCT04334928 Recruiting Randomized Clinical Trial for the Prevention of SARS-CoV-2 I... NCT04384458 Recruiting Comparative Study of Hydroxychloroquine and Ivermectin in CO... NCT04303507 Recruiting Chloroquine/ Hydroxychloroquine Prevention of Coronavirus Di... NCT04408456 Completed Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophy... NCT04341441 Recruiting Will Hydroxychloroquine Impede or Prevent COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.
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