Does death from Covid-19 arise from a multi-step process?
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SciScore for 10.1101/2020.06.01.20116608: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A number of limitations of the data should be recognized. Firstly, the appropriate denominator depends on what the hypothesis is. For cancer, where the multistep model has been most commonly used, the hypothesis is that there are steps involved in developing cancer, so the outcome/numerator is incidence and the denominator is total …
SciScore for 10.1101/2020.06.01.20116608: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A number of limitations of the data should be recognized. Firstly, the appropriate denominator depends on what the hypothesis is. For cancer, where the multistep model has been most commonly used, the hypothesis is that there are steps involved in developing cancer, so the outcome/numerator is incidence and the denominator is total population; most risk factors for cancer that follow the multistep model (e.g. a genetic mutation) affect incidence and usually not survival (25). In the current context, the outcome is Covid-19 death, and the hypothesis relates to mortality in those who become infected. However, in most cases, only case fatality rates (CFRs) were available, and the denominator was diagnosed cases rather than all infections. A related problem is selective case identification - most cases are identified by testing symptomatic people, and non-symptomatic cases are largely missed, and even in those tested there will be false positive and false negative results (this is also a problem with other respiratory diseases such as pandemic influenza (32)). Given all of these uncertainties, the available data that we have used for these analyses is likely to be subject to inaccuracy and misclassification (of outcome, denominator, or both). However, these uncertainties will not bias the analysis unless they operate with different strengths at different age-groups. For example, if the problem is just that the CRF is double the IFR at each age-group greater than 30 years (because...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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