Hypokalemia in Patients with COVID-19
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SciScore for 10.1101/2020.06.14.20131169: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: The study was approved by the regional ethical committee of Emilia Romagna. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources SPSS 23® was used for statistical analysis. SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Several other limitations of this study must be enunciated. …
SciScore for 10.1101/2020.06.14.20131169: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: The study was approved by the regional ethical committee of Emilia Romagna. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources SPSS 23® was used for statistical analysis. SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Several other limitations of this study must be enunciated. First, we were unable to trace hypokalemia-related clinical manifestations despite the completeness of the electronic chart. Second, the restricted group of patients who underwent urinary examination has reduced the accuracy of analysis to identify the causes of hypokalemia. However, despite the small sample, we have collected comprehensive data on magnesium level, urine sodium and acid-base status. This study is the first report describing in detail the clinical characteristic of hypokalemic patients affected by SARS-CoV-2. Although urine examination was available only in a small number of patients, we traced the potential causes of hyperkalemia, including diuretic therapy, acid-base disorder and corticosteroid therapy, in a cohort of hospitalized patients. Our results support the need to frequently measure the level of serum potassium along with urine K-to-creatinine ratio or 24h potassium excretion in COVID-19 patients in order to improve the management of these patients. Based on the magnitude of the urinary loss, potassium should be supplemented per os or IV, and a careful assessment of the ECG should be performed, especially in concomitance of potentially arrhythmogenic drugs. Further studies are required to investigate the hypothesized cytopathic effect of SARS-CoV-2 on renal tubular cells and other secondary injury mechanisms such as hypoxia and cytokine storm.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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