Diagnosis of SARS-CoV-2 in children: accuracy of nasopharyngeal swab compared to nasopharyngeal aspirate

  1. On behalf of Testing Pediatric Covid-19 (TPC-19)
  2. Giada Maria Di Pietro
  3. Ester Capecchi
  4. Ester Luconi
  5. Giovanna Lunghi
  6. Samantha Bosis
  7. Giuseppe Bertolozzi
  8. Barbara Cantoni
  9. Giuseppe Marano
  10. Patrizia Boracchi
  11. Elia Biganzoli
  12. Silvana Castaldi
  13. Paola Marchisio

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Abstract

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  1. ScreenIT

    SciScore for 10.1101/2020.08.20.20178012: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study has some limitations. Firstly, the different order in obtaining the specimens; so the data are not uniform. Secondly, the small number of the sample. Another limitation is the lack of data about signs and symptoms of patients who underwent NPA and NS, and the resulting impossibility to describe a correlation between the isolation of SARS-CoV-2 and the clinical features. Finally, an analysis about the relationship between the viral load and the infectivity is not reported. It has been demonstrated that the identification of the virus on a specimen does not necessary correlate with infectivity, there are indeed multiple reports which attest a prolonged viral shedding after symptoms resolution in COVID-19.29 In our department, among children whose tests were positive, three continued to be positive to NS or NPA or both, for 9 weeks. These findings agree with several studies which demonstrated the prolonged viral shedding of children30,31.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1007/s10096-020-04131-z
  3. Version published to 10.1101/2020.08.20.20178012v1 on medRxiv