Practical challenges to the clinical implementation of saliva for SARS-CoV-2 detection
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SciScore for 10.1101/2020.08.27.20170589: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study had several limitations. Firstly, due to a limited number of samples per each patient group, we are not able to make inferences on performance in any one particular setting. Samples were collected by various …
SciScore for 10.1101/2020.08.27.20170589: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study had several limitations. Firstly, due to a limited number of samples per each patient group, we are not able to make inferences on performance in any one particular setting. Samples were collected by various healthcare workers without specific training or instruction in saliva collection, and submitted from diverse locations leading to variable transport times. However, these factors do provide a realistic view of the utility of saliva samples in clinical settings. The evaluation of the stability of SARS-CoV-2 viral RNA in human saliva samples without transport media was limited to 48 hours by the available volume of saliva from patients and volunteers. However, the vast majority of samples received by our laboratory for SARS-CoV-2 detection are processed in less than 48 hours, and thus these results have relevance to many clinical diagnostic laboratories. Further study may include establishment of a reliable method for saliva collection in patient populations with barriers (e.g., LTC residents, intubated patients in critical care units), and optimization of high-throughput automated laboratory instruments to accommodate these highly viscous specimens collected as part of mass surveillance measures.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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