Methylprednisolone in adults hospitalized with COVID-19 pneumonia
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SciScore for 10.1101/2020.06.17.20133579: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Institutional Review Boards of participating hospitals, and patients gave informed consent.
Consent: The study was approved by the Institutional Review Boards of participating hospitals, and patients gave informed consent.Randomization Study design: GLUCOCOVID is a partially randomized preference, open-label, controlled, two-arm, parallel-group, trial conducted at 5 hospitals in Spain in April-May 2020. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers …
SciScore for 10.1101/2020.06.17.20133579: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Institutional Review Boards of participating hospitals, and patients gave informed consent.
Consent: The study was approved by the Institutional Review Boards of participating hospitals, and patients gave informed consent.Randomization Study design: GLUCOCOVID is a partially randomized preference, open-label, controlled, two-arm, parallel-group, trial conducted at 5 hospitals in Spain in April-May 2020. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. Firstly, the small sample size. Indeed, it is a pre-planned interim analysis of an ongoing trial, not powered to explore the association of treatment with individual endpoints. However, we feel the results are important to inform clinical decisions while ongoing larger controlled randomized trials are completed. Secondly, the inclusion of a preferential arm theoretically hampers the balance of baseline characteristics across study arms. Nevertheless, actual differences were not large, as shown in table 1. In fact, the beneficial effect of MP was observed not only in the analysis combining the randomized and preferential arms, but also when only the randomized arms were compared, reinforcing the conclusions of the study. Third, there might be differences in patient management across the participating hospitals. Fortunately, in practice, the protocols for COVID-19 were very similar, because they were based on the recommendations of the Spanish Ministry of Health, including the use of azithromycin, hydroxychloroquine, and lopinavir/ritonavir. Fourth, due to the rapidly deteriorating course of some COVID-19 cases, they escalated to ICU or NIV within the first 24 hours of inclusion in the study. Therefore, they received only 1-2 doses of MP, thus impeding to assess the effect of the drug. We included a per-protocol analysis excluding those patients to avoid their confounding effect. Our study shows that MP improves the prognosis of COVID-19. Eluc...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.06.17.20133579: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement The study was approved by the Institutional Review Boards of participating hospitals , and patients gave informed consent . Randomization Multicentric , partially randomized , preference , open-label trial , including adults with COVID-19 pneumonia , impaired gas exchange and biochemical evidence of hyper-inflammation . Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
- Our study has several limitations.
- Firstly, the small sample size.
- Indeed, it is a pre-planned interim analysis of an …
SciScore for 10.1101/2020.06.17.20133579: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement The study was approved by the Institutional Review Boards of participating hospitals , and patients gave informed consent . Randomization Multicentric , partially randomized , preference , open-label trial , including adults with COVID-19 pneumonia , impaired gas exchange and biochemical evidence of hyper-inflammation . Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
- Our study has several limitations.
- Firstly, the small sample size.
- Indeed, it is a pre-planned interim analysis of an ongoing trial, not powered to explore the association of treatment with individual endpoints.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from OddPub: We did not find a statement about open data. We also did not find a statement about open code. Researchers are encouraged to share open data when possible (see Nature blog).
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.
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