Impact of stopping therapy during the SARS-CoV-2 pandemic in persons with lymphoma

  1. Shenmiao Yang
  2. Dong Dong
  3. Hongfei Gu
  4. Robert Peter Gale
  5. Jun Ma
  6. Xiaojun Huang

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Abstract

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  1. Version published to 10.1007/s00432-020-03426-0
  2. ScreenIT

    SciScore for 10.1101/2020.09.28.20203083: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The study was approved by the Ethics Committees of Peking University Peoples’ Hospital according to tenets of the Declaration of Helsinki (Register number 2020PHB173).
    Consent: Electronic informed consent was obtained from all respondents who could withdraw at any time during the survey without prejudice.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Scores of five functioning scales (physical, role, emotional, cognitive, and social functioning), eight symptom scales (fatigue, nausea/vomiting, pain, dyspnea, sleep disturbances, appetite loss, constipation, and diarrhea), fiscal impact and overall HRQoL were calculated using the EORTC QLQ-C30 instrument (Aaronson, et al. 1993).
    EORTC
    suggested: (EORTC, RRID:SCR_004070)
    Statistical analyses were performed with SPSS 12.0 (IBM SPSS Statistics, New York, US).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are several limitations of our study. Our survey was online with potential selection biases. For example, our patient respondents were younger than most lymphoma patients, perhaps because of increased internet familiarity and/or access. Our normal cohort had a much younger age than patient and caregiver respondents. Because our survey was cross-sectional it was not possible to compare anxiety and HRQoL in the same respondent before and during the pandemic. In our comparison of HRQoL with a pre-pandemic cohort we were short of data on lymphoma stage so we cannot know if the better HRQoL we observed during the pandemic might result from patients with less advanced lymphoma (Stewart, et al. 2016).

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.09.28.20203083v1 on medRxiv