Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors
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SciScore for 10.1101/2021.06.15.21259003: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: They were enrolled in the study after obtaining written consent. Sex as a biological variable Seven PCOS datasets which compared gene expression patterns of ovarian cells/tissues in control women and women with PCOS were selected and downloaded from the GEO database [31]. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Microarray data analysis: The Gene Expression Omnibus (GEO, http://www. http://ncbi.nlm.nih.gov/geo/) database was searched for gene expression datasets on PCOS compared to controls (Table 1). Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)The limma … SciScore for 10.1101/2021.06.15.21259003: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: They were enrolled in the study after obtaining written consent. Sex as a biological variable Seven PCOS datasets which compared gene expression patterns of ovarian cells/tissues in control women and women with PCOS were selected and downloaded from the GEO database [31]. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Microarray data analysis: The Gene Expression Omnibus (GEO, http://www. http://ncbi.nlm.nih.gov/geo/) database was searched for gene expression datasets on PCOS compared to controls (Table 1). Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)The limma package in R was used to identify differentially expressed genes [32]. limmasuggested: (LIMMA, RRID:SCR_010943)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
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