Observer agreement and clinical significance of chest CT reporting in patients suspected of COVID-19
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SciScore for 10.1101/2020.05.07.20094102: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Institutional review board was approved and written informed consent waived.
Consent: Institutional review board was approved and written informed consent waived.Randomization not detected. Blinding Image analysis: All CT-scans were analyzed by 8 readers, including 2 senior emergency physicians (TP, DB, with 10 years of experience each), 2 radiology residents (HT, NC, 4 and 5 years of experience), 2 senior general radiologists (LM, EM, 6 and 9 years of experience) and 2 senior thoracic radiologists (MPD, AK, 23 and 25 years of experience), blindly to RT-PCR results and final diagnosis. Power Analysis not detected. Sex as a biological variable not detected. Table …
SciScore for 10.1101/2020.05.07.20094102: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Institutional review board was approved and written informed consent waived.
Consent: Institutional review board was approved and written informed consent waived.Randomization not detected. Blinding Image analysis: All CT-scans were analyzed by 8 readers, including 2 senior emergency physicians (TP, DB, with 10 years of experience each), 2 radiology residents (HT, NC, 4 and 5 years of experience), 2 senior general radiologists (LM, EM, 6 and 9 years of experience) and 2 senior thoracic radiologists (MPD, AK, 23 and 25 years of experience), blindly to RT-PCR results and final diagnosis. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Chest CT protocols: Chest CT-scans were acquired on a multidetector-row CT (Canon Aquilion PRIME or GENESIS) without contrast medium injection. GENESISsuggested: (Genesis, RRID:SCR_015775)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Despite limitations in sensitivity and result delays, the RT-PCR remains the diagnostic reference and chest CT is not recommended for screening by most Radiology Societies [6,15,19,20]. According to a recent consensus statement from the Fleischner Society [20], imaging may be indicated for diagnosis when RT-PCR is negative or unavailable in patients having risk factors for worsening or moderate-to-severe respiratory signs. In our study, most patients who had chest CT at the emergency room had indeed either moderate or severe clinical features or comorbidities. Chest CT helped addressing or transferring patients into the proper, COVID-19 or not COVID-19, hospitalization area, especially those needing urgent decision, before the RT-PCR result was provided. Chest CT could favor re-testing in cases with negative RT-PCR [12]. Patients with a first negative RT-PCR and a chest CT considered «compatible» have been more frequently re-tested and had a subsequent PCR more frequently positive, as compared to patients with a first negative RT-PCR and a chest CT considered «not evocative». Of note, two patients had a final COVID-19 retained diagnosis based on typical clinical and CT presentation and evolution, despite two negative nasopharyngeal RT-PCR tests. To date, performances of chest CT have been analyzed according to a binary consideration, i.e. CT positive or negative for COVID-19 pneumonia, using RT-PCR as reference. Most studies have reported high sensitivity, up to 97% [4,5,21] ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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