Acute Upper Airway Disease in Children With the Omicron (B.1.1.529) Variant of SARS-CoV-2—A Report From the US National COVID Cohort Collaborative

  1. Blake Martin
  2. Peter E. DeWitt
  3. Seth Russell
  4. L. Nelson Sanchez-Pinto
  5. Melissa A. Haendel
  6. Richard Moffitt
  7. Tellen D. Bennett

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Abstract

This cohort study uses data from the US National COVID Cohort Collaborative to evaluate upper airway infections in children during the surge of the Omicron (B.1.1.529) variant of SARS-CoV-2 in the US.

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  1. Version published to 10.1001/jamapediatrics.2022.1110
  2. ScreenIT

    SciScore for 10.1101/2022.01.27.22269865: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The N3C Data Enclave, data transfer from sites to N3C, and this analysis were approved under separate institutional review board protocols as documented elsewhere1.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Among all children in N3C <19-years-old with a positive SARS-CoV-2 test (polymerase chain reaction, antigen, or antibody), we identified those with a croup or tracheitis diagnosis.
    antigen,
    suggested: None
    antibody
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    A limitation of this analysis is that diagnosis codes will only be present for completed hospitalizations in N3C; children who are still hospitalized are not represented. Although many children with acute UAI are managed as outpatients, those with severe croup and/or tracheitis are at risk of cardiac arrest from rapid-onset upper airway obstruction. They may require therapies typically provided in intensive care units including frequent administration of nebulized racemic epinephrine, helium/oxygen mixtures, and intubation. While SARS-CoV-2 pediatric UAI rates are not overwhelmingly high, understanding this new clinical phenotype is important to health systems under severe strain. Anticipation of the potential for acute upper airway obstruction may guide therapeutic decision-making and hospital planning for available equipment and personnel.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2022.01.27.22269865v1 on medRxiv