Association of Age and Pediatric Household Transmission of SARS-CoV-2 Infection
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SciScore for 10.1101/2021.03.29.21254565: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: We obtained ethics approval from Public Health Ontario’s Research Ethics Board. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Addresses were then matched between cases using a natural language processing algorithm from Python’s “sklearn” library in order to identify multi-case households. Python’ssuggested: (PyMVPA, RRID:SCR_006099)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We …SciScore for 10.1101/2021.03.29.21254565: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: We obtained ethics approval from Public Health Ontario’s Research Ethics Board. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Addresses were then matched between cases using a natural language processing algorithm from Python’s “sklearn” library in order to identify multi-case households. Python’ssuggested: (PyMVPA, RRID:SCR_006099)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has some limitations that should be acknowledged. First, there is the possibility of misclassifying household transmission if secondary case infection was truly acquired outside of the household, or if the true index case of the household was untested. This is particularly relevant for pediatric cases due to their increased probability of having mild or asymptomatic infection, and thus increased probability of infection being missed. We attempted to account for this in sensitivity analyses by modifying the secondary case definition from 1-14 days to 2-14 and 4-14 days, and restricting analysis to symptomatic cases only. Second, this study used multiple evolving data systems for reporting COVID-19 cases in Ontario. As a result, there was some inconsistency regarding how symptoms were reported, which may result in some misclassification of symptomatic cases. We carefully examined the reporting practices over the months covered in the study, and selected a combination of variables (symptoms reported, symptom onset date available, and/or asymptomatic flag) we felt reflected the most likely symptom status of cases. Third, we could not reliably calculate SARs in the study as we did not know the number of non-infected contacts in households for the full cohort. However, after controlling for individual-level household size within the subset of the cohort with this information available, our conclusions were unaltered. This study also has several strengths. This is a large...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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