Estimated Health Outcomes and Costs of COVID-19 Prophylaxis With Monoclonal Antibodies Among Unvaccinated Household Contacts in the US
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SciScore for 10.1101/2021.08.31.21262923: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This analysis also has limitations. First, population structure may have changed due to housing insecurity, work disruption, and general adaptation during more than a year of social distancing in response to COVID-19 pandemic. Second, there was missing data in confirmed cases, especially about race, hospitalizations, and deaths. Third, we modeled the whole US population without differentiating regionally for vaccine coverage, household …
SciScore for 10.1101/2021.08.31.21262923: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This analysis also has limitations. First, population structure may have changed due to housing insecurity, work disruption, and general adaptation during more than a year of social distancing in response to COVID-19 pandemic. Second, there was missing data in confirmed cases, especially about race, hospitalizations, and deaths. Third, we modeled the whole US population without differentiating regionally for vaccine coverage, household composition, and COVID-19 case activity. Fourth, our transmission probability parameter from the clinical trial does not incorporate increased infectiousness due to the delta variant, which is still being characterized in the household setting.29 Fifth, SARS-CoV-2 viral evolution causes challenges in the forecasting the future PEP benefit, as new SARS-CoV-2 variants may reduce mAb PEP efficacy. Some variants have already demonstrated resistance to neutralization by monoclonal antibodies, though early preclinical and human studies indicate protection by imdev/casi against the SARS-CoV-2 variants of concern including the delta variant.15 Finally, we assume that unvaccinated individuals are susceptible to SARS-CoV-2 infection without accounting for partial immunity from prior SARS-CoV-2 infection.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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