Association of SARS-CoV-2 Seropositivity and Symptomatic Reinfection in Children in Nicaragua
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Abstract
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SciScore for 10.1101/2022.01.03.22268684: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics statement: The study was approved by the Institutional Review Boards of the Nicaraguan Ministry of Health and the University of Michigan.
Consent: Written informed consent was obtained from a parent/guardian of all participants, and verbal assent was obtained from children aged ≥6 years.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This analysis does have several limitations. First, the initial serology samples …
SciScore for 10.1101/2022.01.03.22268684: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics statement: The study was approved by the Institutional Review Boards of the Nicaraguan Ministry of Health and the University of Michigan.
Consent: Written informed consent was obtained from a parent/guardian of all participants, and verbal assent was obtained from children aged ≥6 years.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This analysis does have several limitations. First, the initial serology samples were collected in February/March 2020—largely before the first wave of SARS-CoV-2 infections in Nicaragua. As such, it is possible that some infections, particularly milder presentations, were missed. It is likely, however, that most of these infections were captured via PCR or by ELISA testing of samples collected in late 2020 and early 2021. Additionally, to assess illness severity of infections detected only by ELISA, we relied on retrospective surveys that may have been subject to recall bias. Fortunately, this is likely to have affected only the mildest of cases as the PCR testing criteria were quite broad—particularly after being expanded in June 2020. Finally, as a community-based, prospective cohort study, we were underpowered to assess the burden of MIS-C and death associated with SARS-CoV-2 infection due to their rarity. Through this prospective cohort of Nicaraguan children, we were able to assess the impact of SARS-CoV-2 infection on children aged 0-14 years at the community level. We observed high rates of infection, with 51.6% of children having been infected with SARS-CoV-2 over the course of the study. While illness was generally mild, severe illness and prolonged sequelae were observed—most often among children <2 years. Finally, symptomatic re-infection was quite common, with lower protection among children aged >10 years, suggesting important age-associated differences in immun...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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