Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy
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SciScore for 10.1101/2021.12.15.21267849: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The Mass General-Brigham Institutional Review Board approved all aspects of this study, with a waiver of informed consent as no patient contact was required, the study was considered to be minimal risk, and consent could not feasibly be obtained.
Consent: The Mass General-Brigham Institutional Review Board approved all aspects of this study, with a waiver of informed consent as no patient contact was required, the study was considered to be minimal risk, and consent could not feasibly be obtained.Sex as a biological variable (During the period under investigation, routine testing of asymptomatic pregnant women was not conducted). Randomization not detected. Blinding not detected. Power … SciScore for 10.1101/2021.12.15.21267849: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The Mass General-Brigham Institutional Review Board approved all aspects of this study, with a waiver of informed consent as no patient contact was required, the study was considered to be minimal risk, and consent could not feasibly be obtained.
Consent: The Mass General-Brigham Institutional Review Board approved all aspects of this study, with a waiver of informed consent as no patient contact was required, the study was considered to be minimal risk, and consent could not feasibly be obtained.Sex as a biological variable (During the period under investigation, routine testing of asymptomatic pregnant women was not conducted). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: Our results must be recognized as preliminary given the limited duration of follow-up. In particular, we cannot exclude the possibility that additional neurodevelopmental effects will become apparent later in life – indeed, the offspring analyzed here are younger than the age at which neurodevelopmental disorders such as autism are typically diagnosed. Conversely, there may be a form of ascertainment bias arising from greater concern for offspring of mothers who were ill during pregnancy – that is, parents may be more inclined to seek evaluation, or clinicians more inclined to diagnose or refer for evaluation. Our retrospective study design and reliance on ICD-10 diagnosis codes also lacks the sensitivity of a prospective cohort study that incorporates detailed neurocognitive phenotyping; such studies will be important to better define the impact, if any, of maternal SARS-CoV-2 infection. As an ‘open’ health system, we cannot exclude the possibility of misclassification, as mothers classified as SARS-CoV-2 negative may have received a positive test result or care for SARS-CoV-2 illness outside of our system, and offspring may receive follow-up in another health system. Such misclassification should occur completely at random – i.e., there is no clear reason that SARS-CoV-2-exposed offspring delivered in a specific health system would be less likely to receive ongoing care in that system. In general, these effects of misclassified exposure or outcome would tend to...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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