Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 Vaccine

  1. Koichi Furukawa
  2. Lidya Handayani Tjan
  3. Yukiya Kurahashi
  4. Silvia Sutandhio
  5. Mitsuhiro Nishimura
  6. Jun Arii
  7. Yasuko Mori

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Abstract

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  1. Version published to 10.1001/jamanetworkopen.2022.10780
  2. ScreenIT

    SciScore for 10.1101/2022.01.25.22269735: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsConsent: This study was carried out after written consent was obtained from all participants.
    IRB: Ethical approval: This study was approved by the ethical committee of Kobe University Graduate School of Medicine (approval code: B200200).
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analysis: GraphPad Prism software (ver. 8.4.3) and STATA software (ver. 14.2) were used for the statistical analysis and preparation of figures.
    GraphPad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)
    STATA
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2022.01.25.22269735v2 on medRxiv
  4. Version published to 10.1101/2022.01.25.22269735v1 on medRxiv