Estimation of the Timing and Intensity of Reemergence of Respiratory Syncytial Virus Following the COVID-19 Pandemic in the US

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Abstract

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  1. SciScore for 10.1101/2021.07.19.21260817: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are several caveats to our results. First, we did not have explicit data on the level of virus introduction or the effects of lack of boosting on the duration of protection provided to infants by transplacentally-acquired antibodies to RSV. Although we explored a range of values, it is possible that the real values are outside of the range in our models. Our model predictions are most sensitive to the level of RSV introduction. Additional data on these factors will be helpful for future modeling of RSV transmission dynamics. Research on the relationship between virus exposure and the duration of transplacentally-acquired immunity in infants may also help to explain discrepancies in the efficacy of maternal vaccines across different transmission settings.50 Second, we used historical inpatient data to fit our transmission models. However, the intensity and seasonality of RSV epidemics may have changed over the past few years. To address this possibility, we explored a variety of intensity levels and both annual and biennial cycles with data from different states in our sensitivity analysis (see Figure S7-S16). Also, ongoing RSV surveillance data from California,51 Florida,52 Minnesota,53 Oregon,54 and Texas55 suggests that RSV activity has been very consistent over recent years. Finally, there are other possible factors influencing re-emergent RSV epidemics, such as the impact of introduction of RSV vaccines and monoclonal antibody.56 As the extended half-life antibody a...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

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