Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection
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Abstract
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SciScore for 10.1101/2021.09.16.21263576: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethical approval was obtained from the Johns Hopkins University Institutional Review Board. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations include defining SARS-CoV-2 infection as positive PCR, potentially misclassifying HWs with unconfirmed prior infection. Further study is warranted to determine …
SciScore for 10.1101/2021.09.16.21263576: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethical approval was obtained from the Johns Hopkins University Institutional Review Board. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations include defining SARS-CoV-2 infection as positive PCR, potentially misclassifying HWs with unconfirmed prior infection. Further study is warranted to determine whether this increased post-vaccination antibody durability in previously infected individuals is attributable to number of exposures, interval between exposures, or a complex interplay between natural and vaccine-derived immunity. Given the prominent role of serum spike antibodies and virus neutralization ability as correlates of protection, and waning antibody levels in HWs, urgent studies are needed to determine how serological testing can inform optimal vaccine timing and the need for booster doses.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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