Effect of a Single High Dose of Vitamin D 3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19
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SciScore for 10.1101/2020.11.16.20232397: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Committee of Clinical Hospital of the School of Medicine of the University of Sao Paulo and by the Ethics Committee of Ibirapuera Field Hospital.
Consent: The participants provided written informed consent before being enrolled in the study (Ethics Committee Approval Number 30959620.4.0000.0068).Randomization Study design and treatment: This was a multicenter, double-blind, parallel-group, randomized placebo-controlled trial. Blinding not detected. Power Analysis By considering a power of 80% and a 2-sided significance level of 5% (α = .05), the total sample was estimated to be 208 patients (104 in each arm). Sex as a … SciScore for 10.1101/2020.11.16.20232397: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Committee of Clinical Hospital of the School of Medicine of the University of Sao Paulo and by the Ethics Committee of Ibirapuera Field Hospital.
Consent: The participants provided written informed consent before being enrolled in the study (Ethics Committee Approval Number 30959620.4.0000.0068).Randomization Study design and treatment: This was a multicenter, double-blind, parallel-group, randomized placebo-controlled trial. Blinding not detected. Power Analysis By considering a power of 80% and a 2-sided significance level of 5% (α = .05), the total sample was estimated to be 208 patients (104 in each arm). Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04449718 Completed Vitamin D Supplementation in Patients With COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.11.16.20232397: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Methods The study was approved by the Ethics Committee of Clinical Hospital of the School of Medicine of the University of Sao Paulo and by the Ethics Committee of Ibirapuera Field Hospital. Randomization Design, Setting, and Participants: This is a multicenter, double-blind, randomized, placebo-controlled trial conducted in two centers (a quaternary hospital and a field hospital) in Sao Paulo, Brazil. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data …
SciScore for 10.1101/2020.11.16.20232397: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Methods The study was approved by the Ethics Committee of Clinical Hospital of the School of Medicine of the University of Sao Paulo and by the Ethics Committee of Ibirapuera Field Hospital. Randomization Design, Setting, and Participants: This is a multicenter, double-blind, randomized, placebo-controlled trial conducted in two centers (a quaternary hospital and a field hospital) in Sao Paulo, Brazil. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
Limitations This trial has several limitations. First, the sample size could have been underpowered to detect significant changes for the secondary outcomes. Second, as the patients had several coexisting diseases and were subjected to a diverse medication regimen, the results could have been affected by the heterogeneity of the sample and its treatment. Third, the proportion of patients with 25-hydroxyvitamin D deficiency enrolled in this study was considerably lower than those reported in other cohorts,23 possibly as a consequence of differences in geographic locations. Although we conduced sensitivity analyses involving patients with 25-hydroxyvitamin D deficiency, one could argue that they could have been underpowered, as previously pointed out. Therefore, caution should be exercised in generalizing these findings to patients from other geographical regions. Finally, the findings should be also confined to the dose and supplementation strategy used in this trial. Further studies should determine whether preventive or early vitamin D3 supplementation could be useful in the treatment of patients with COVID- 19, especially those with a mild or moderate disease.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04449718 Completed Vitamin D Supplementation in Patients With COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.
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