Showing page 1 of 8 pages of list content

  1. SOD1 is a synthetic lethal target in PPM1D -mutant leukemia cells

    This article has 23 authors:
    1. Linda Zhang
    2. Joanne I. Hsu
    3. Etienne D. Braekeleer
    4. Chun-Wei Chen
    5. Tajhal D. Patel
    6. Hidetaka Urya
    7. Anna G. Guzman
    8. Alejandra G. Martell
    9. Sarah M. Waldvogel
    10. Ayala Tovy
    11. Elsa Callen
    12. Rebecca Murdaugh
    13. Rosemary Richard
    14. Sandra Jansen
    15. Lisenka Vissers
    16. Bert B.A. de Vries
    17. Andre Nussenzweig
    18. Shixia Huang
    19. Cristian Coarfa
    20. Jamie N. Anastas
    21. Koichi Takahashi
    22. George Vassiliou
    23. Margaret A. Goodell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Gain-of-function mutations and amplifications of PPM1D are found across several human cancers and are associated with advanced tumor stage, worse prognosis, and increased lymph node metastasis. Unfortunately, clinical translation has so far not been possible due to the lack of PPM1D inhibitors with favorable pharmacokinetic properties. This useful study leveraged CRISPR/Cas9 screening to identify that SOD1 inhibition is synthetic lethal with PPM1D mutation in leukemia, although the mechanistic analyses were incomplete.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  2. Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues

    This article has 14 authors:
    1. Wanyoung Lim
    2. Inwoo Hwang
    3. Jiande Zhang
    4. Zhenzhong Chen
    5. Jeonghun Han
    6. Jaehyung Jeon
    7. Bon-Kyoung Koo
    8. Sangmin Kim
    9. Jeong Eon Lee
    10. Kenneth J. Pienta
    11. Sarah R. Amend
    12. Robert H. Austin
    13. Jee-Yin Ahn
    14. Sungsu Park
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study based on the use of Cancer Drug Resistance Accelerator (CDRA) chip is valuable as a platform technology to assess chemoresistance mechanisms. The strength is convincing from the technological point of view. However, the use of a single cell line model and the lack of mechanistic insights could be improved.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  3. DePARylation is critical for S phase progression and cell survival

    This article has 13 authors:
    1. Litong Nie
    2. Chao Wang
    3. Xiaoguang Liu
    4. Min Huang
    5. Xu Feng
    6. Mengfan Tang
    7. Siting Li
    8. Qinglei Hang
    9. Hongqi Teng
    10. Xi Shen
    11. Li Ma
    12. Boyi Gan
    13. Junjie Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors' finding that PARG hydrolase removal of polyADP-ribose (PAR) protein adducts generated in response to the presence of unligated Okazaki fragments is important for S-phase progression is potentially valuable, but the evidence is incomplete, and identification of relevant PARylated PARG substrates in S-phase is needed to understand the role of PARylation and dePARylation in S-phase progression. Their observation that human ovarian cancer cells with low levels of PARG are more sensitive to a PARG inhibitor, presumably due to the accumulation of high levels of protein PARylation, suggests that low PARG protein levels could serve as a criterion to select ovarian cancer patients for treatment with a PARG inhibitor drug.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  4. Single-cell Sequencing Highlights Heterogeneity and Malignant Progression in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

    This article has 17 authors:
    1. Dan-Dan Zou
    2. Ya-Zhou Sun
    3. Xin-Jie Li
    4. Wen-Juan Wu
    5. Dan Xu
    6. Yu-Tong He
    7. Jue Qi
    8. Ying Tu
    9. Yang Tang
    10. Yun-Hua Tu
    11. Xiao-Li Wang
    12. Xing Li
    13. Feng-Yan Lu
    14. Ling Huang
    15. Heng Long
    16. Li He
    17. Xin Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study delineates the molecular changes driving the progression from actinic keratosis (AK) to cutaneous squamous cell carcinoma (cSCC). Using state-of-the-art single-cell RNA profiling of 138,982 cells from 13 samples of six patients including AK, squamous cell carcinoma in situ (SCCIS), cSCC, and their matched normal tissues, thus covering comprehensive clinical courses of cSCC, the authors provide an invaluable data resource. This study identified several previously unreported and interesting candidate genes involved in different stages of the malignant progression of skin neoplasias, which have been validated in situ, and partially in vitro. Although data analysis needs improvement and comparison to other published data sets to fully support the claims and conclusions, these findings substantially advance our understanding of the molecular changes leading to skin cancer.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  5. Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics

    This article has 13 authors:
    1. Timothy J. Walker
    2. Eduardo Reyes-Alvarez
    3. Brandy D. Hyndman
    4. Michael G. Sugiyama
    5. Larissa C.B. Oliveira
    6. Aisha N. Rekab
    7. Mathieu J.F. Crupi
    8. Rebecca Cabral-Dias
    9. Qianjin Guo
    10. Patricia L.M. Dahia
    11. Douglas S. Richardson
    12. Costin N. Antonescu
    13. Lois M. Mulligan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study highlights new insights into the mechanism of pheochromocytoma pathogenesis that remains poorly understood. In the context of hereditary syndromes, such as multiple endocrine neoplasia 2 (MEN-2), where RET mutation is the major driver of thyroid, parathyroid, and adrenal pathologies, including pheochromocytoma, this mechanistic dissection of RET and TMEM127 is fundamentally sound. While the significance was deemed important, the strength of the evidence was found to be solid, although additional validation work would strengthen the findings.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  6. ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System

    This article has 13 authors:
    1. Sen Qin
    2. Yawei Xu
    3. Shimiao Yu
    4. Wencong Han
    5. Shiheng Fan
    6. Wenxiang Ai
    7. Kenan Zhang
    8. Yizhou Wang
    9. Xuehong Zhou
    10. Qi Shen
    11. Kan Gong
    12. Luyang Sun
    13. Zheng Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding for the treatment of PCCs by sequencing 16 tumor specimens from five patients with pheochromocytomas by single-cell transcriptomics and proposing a new molecular classification criterion based on the sequencing results and characterization of tumor microenvironmental features. The evidence supporting the claims of the authors is solid, although the inclusion of more patient samples would strengthen the study's conclusions. The work will be of interest to clinicians or medical biologists working on rare pheochromocytomas (PCCs).

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  7. DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

    This article has 2 authors:
    1. Jose Mario Bello Pineda
    2. Robert K. Bradley
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the association between DUX4 expression with features of immune evasion in human tissue and clinical outcomes in patients with advanced urothelial cancer. The evidence supporting the claims of the authors is convincing, using a range of corroborative statistical techniques. While of significant interest to those working on the immune biology of urothelial cancer and drug discovery, this work does not provide any mechanistic insights into the role of DUX4 and immune suppression and the assessment on clinical samples forms the discovery part of a biomarker program, requiring further cohorts for validation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  8. DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

    This article has 2 authors:
    1. Jose Mario Bello Pineda
    2. Robert K. Bradley
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the association between DUX4 expression with features of immune evasion in human tissue and clinical outcomes in patients with advanced urothelial cancer. The evidence supporting the claims of the authors is convincing, using a range of corroborative statistical techniques. While of significant interest to those working on the immune biology of urothelial cancer and drug discovery, this work does not provide any mechanistic insights into the role of DUX4 and immune suppression and the assessment on clinical samples forms the discovery part of a biomarker program, requiring further cohorts for validation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  9. NanoPDLIM2 enhanced efficacy of PD-1 blockade and chemotherapy in mouse lung cancers

    This article has 7 authors:
    1. Fan Sun
    2. Pengrong Yan
    3. Yadong Xiao
    4. Hongqiao Zhang
    5. Steven D. Shapiro
    6. Gutian Xiao
    7. Zhaoxia Qu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The reviewers have found the work to be valuable to the field of immunotherapy in the treatment of cancer. The data supporting the role of PDLIM2 as a tumor suppressor, and more immediately, as a strategy to improve the efficacy of immunotherapy treatment, was viewed as compelling. However, the results are lacking a completed mechanism, which would substantially expand the impact of the work.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  10. Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

    This article has 12 authors:
    1. Jing Xie
    2. Yafei Xu
    3. Xuhua Liu
    4. Li Long
    5. Ji Chen
    6. Yan Shao
    7. Zhiqing Cai
    8. Zhimin Zhang
    9. Ruixin Zhou
    10. Jiarong Leng
    11. Xiaochun Bai
    12. Qiancheng Song
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study describes a potential role for mechanical stimulation on non-small cell lung cancer (NSCLC) development. The findings are important and their observations are interesting, as models to study exercise in a mouse cancer setting would have practical implications beyond lung cancer, and biological roles of osteocytes in bone metastatic cancer is an area of great interest for potential therapy development. However, the methods and data interpretation are incomplete and the claims of osteocytes inducing tumor dormancy are overstated. The mechanism by which osteocytes affect tumor cells is not clear and the authors' theory on this remains unproven since much of the data are correlative rather than causative, and adequate controls, data quantification, and confirmation with secondary cell lines are often lacking.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  11. Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen specific tumor cell killing by cytotoxic T cells

    This article has 9 authors:
    1. Ann-Kathrin Mattes
    2. Marta Puig Gamez
    3. Eva Martin
    4. Lukasz Boryn
    5. Praveen Baskaran
    6. Heinrich J. Huber
    7. Michael Schuler
    8. John E. Park
    9. Lee Kim Swee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important research uses complementary CRISPR screening strategies to reveal novel pathways that prevent T cells from killing tumor cells. The evidence presented to support the claims is solid, although some additional assays defining the features of these novel pathways and their clinical relevance are still required. Overall, this work will be of broad interest to immunologists, cancer biologists, and those interested in cell adhesion and cell-cell communication.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  12. Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors

    This article has 7 authors:
    1. Miin S. Lin
    2. Se-Young Jo
    3. Jens Luebeck
    4. Howard Y. Chang
    5. Sihan Wu
    6. Paul S. Mischel
    7. Vineet Bafna
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study of extrachromosomal DNA (ecDNA) aims to identify genes that distinguish ecDNA+ and ecDNA- tumors. This timely study is important in addressing the genes responding to the amplification of the ecDNA. The data presented are for the most part solid, there were concerns regarding the clarity in the description of the analysis methods and whether the evidence for specific genes required to maintain the ecDNA+ state was entirely conclusive.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  13. RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

    This article has 11 authors:
    1. Mengya Zhao
    2. Beiying Dai
    3. Xiaodong Li
    4. Yixin Zhang
    5. Chun Qiao
    6. Yaru Qin
    7. Zhao Li
    8. Qingmei Li
    9. Shuzhen Wang
    10. Yong Yang
    11. Yijun Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Zhao et al describe a novel function for RAPSYN in bcr-abl fusion associated leukemia. They show that RAPSYN stabilizes the oncogenic BCR-ABL fusion protein. Their findings are important and the strength of findings is convincing. The reviewers have made suggestions about further strengthening the rigor by use of more primary samples.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  14. Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

    This article has 65 authors:
    1. Van Thien Chi Nguyen
    2. Trong Hieu Nguyen
    3. Nhu Nhat Tan Doan
    4. Thi Mong Quynh Pham
    5. Giang Thi Huong Nguyen
    6. Thanh Dat Nguyen
    7. Thuy Thi Thu Tran
    8. Duy Long Vo
    9. Thanh Hai Phan
    10. Thanh Xuan Jasmine
    11. Van Chu Nguyen
    12. Huu Thinh Nguyen
    13. Trieu Vu Nguyen
    14. Thi Hue Hanh Nguyen
    15. Le Anh Khoa Huynh
    16. Trung Hieu Tran
    17. Quang Thong Dang
    18. Thuy Nguyen Doan
    19. Anh Minh Tran
    20. Viet Hai Nguyen
    21. Vu Tuan Anh Nguyen
    22. Le Minh Quoc Ho
    23. Quang Dat Tran
    24. Thi Thu Thuy Pham
    25. Tan Dat Ho
    26. Bao Toan Nguyen
    27. Thanh Nhan Vo Nguyen
    28. Thanh Dang Nguyen
    29. Dung Thai Bieu Phu
    30. Boi Hoan Huu Phan
    31. Thi Loan Vo
    32. Thi Huong Thoang Nai
    33. Thuy Trang Tran
    34. My Hoang Truong
    35. Ngan Chau Tran
    36. Trung Kien Le
    37. Thanh Huong Thi Tran
    38. Minh Long Duong
    39. Hoai Phuong Thi Bach
    40. Van Vu Kim
    41. The Anh Pham
    42. Duc Huy Tran
    43. Trinh Ngoc An Le
    44. Truong Vinh Ngoc Pham
    45. Minh Triet Le
    46. Dac Ho Vo
    47. Thi Minh Thu Tran
    48. Minh Nguyen Nguyen
    49. Thi Tuong Vi Van
    50. Anh Nhu Nguyen
    51. Thi Trang Tran
    52. Vu Uyen Tran
    53. Minh Phong Le
    54. Thi Thanh Do
    55. Thi Van Phan
    56. Luu Hong Dang Nguyen
    57. Duy Sinh Nguyen
    58. Van Thinh Cao
    59. Thanh Thuy Thi Do
    60. Dinh Kiet Truong
    61. Hung Sang Tang
    62. Hoa Giang
    63. Hoai Nghia Nguyen
    64. Minh Duy Phan
    65. Le Son Tran
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides insights into the early detection of malignancies with noninvasive methods by developing a framework, which assesses methylation, CNA, and other genomic features. They established a solid model in discriminating malignancies from healthy controls, as well as the ability to distinguish tumor of origin. This important study will demonstrate its practical impacts in the clinic and other researchers of the field.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
  15. ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

    This article has 7 authors:
    1. Elena Farmaki
    2. Aritro Nath
    3. Rena Emond
    4. Kimya L Karimi
    5. Vince K Grolmusz
    6. Patrick A Cosgrove
    7. Andrea H Bild
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the combination treatment of ONC201/TIC10 with everolimus for metastatic ER+ breast cancer. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on breast cancer.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  16. Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records

    This article has 9 authors:
    1. Jessica Xin Hjaltelin
    2. Sif Ingibergsdóttir Novitski
    3. Isabella Friis Jørgensen
    4. Julia Sidenius Johansen
    5. Inna M Chen
    6. Troels Siggaard
    7. Siri Vulpius
    8. Lars Juhl Jensen
    9. Søren Brunak
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings on the symptoms and disease trajectories preceding a diagnosis of pancreatic cancer in Denmark. The evidence supporting the claims of the authors is solid, although an error analysis of the text mining evaluation results and a discussion on how the findings can be applied in practice would strengthen the study. The work will be of interest to public health researchers and clinicians working on pancreatic cancer.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  17. RAF conformational autoinhibition and 14-3-3 proteins promote paradoxical activation

    This article has 9 authors:
    1. Gaurav Mendiratta
    2. Kodye Abbott
    3. Yao-Cheng Li
    4. Jingting Yu
    5. Jianfeng Huang
    6. Maxim N. Shokhirev
    7. Thomas McFall
    8. Geoffrey M. Wahl
    9. Edward C. Stites
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study uses mathematical modelling to demonstrate that conformational autoinhibition of the RAF kinase is an important feature of its paradoxical activation by pharmacological inhibitors. This part of the theoretical analysis is highly compelling but its extension to the investigation of how the binding of 14-3-3 adaptors additionally contributes to the paradoxical activation phenomenon is incomplete and would benefit from more rigorous experimental validation. With the experimental part addressing 14-3-3-dependent regulation strengthened or the 14-3-3 part completely removed, this paper would be of considerable interest to cell biologists and cancer biologists, ultimately paving the way for improved RAF therapeutics.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  18. Isoform-specific Disruption of the TP73 Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin

    This article has 10 authors:
    1. Xiangmudong Kong
    2. Wensheng Yan
    3. Wenqiang Sun
    4. Yanhong Zhang
    5. Hee Jung Yang
    6. Mingyi Chen
    7. Hongwu Chen
    8. Ralph W. de Vere White
    9. Jin Zhang
    10. Xinbin Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      TP73 is a member of the p53 family of tumor suppressors. The authors provide compelling evidence that a TAp73-alpha to TAp73-gamma switch could be a frequent phenomenon in human cancers and provide novel evidence that TAp73-gamma has oncogenic functions via Leptin. The authors provide a substantial amount of high-quality data and convincingly demonstrate a novel function of this specific isoform of p73 in lipid metabolism and tumorigenesis.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  19. Treatment with Tumor-Treating Fields (TTFields) Suppresses Intercellular Tunneling Nanotube Formation In Vitro and Upregulates Immuno-Oncologic Biomarkers In Vivo in Malignant Mesothelioma

    This article has 12 authors:
    1. Akshat Sarkari
    2. Sophie Korenfeld
    3. Karina Deniz
    4. Katherine Ladner
    5. Phillip Wong
    6. Sanyukta Padmanabhan
    7. Rachel I Vogel
    8. Laura Sherer
    9. Naomi Courtemanche
    10. Clifford J Steer
    11. Kerem Wainer-Katsir
    12. Emil Lou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Overall, this is an interesting topic of study, and the conclusions could be of relevance more broadly. However, mechanistic support, limited TTF frequencies/timing, and visual support of the quantitative data would be critical in order to provide convincing and rigorous support for this interesting concept.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  20. Mutant SF3B1 promotes PDAC malignancy through TGF-β resistance

    This article has 8 authors:
    1. Patrik T. Simmler
    2. Tamara Mengis
    3. Kjong-Van Lehmann
    4. André Kahles
    5. Tinu Thomas
    6. Gunnar Rätsch
    7. Markus Stoffel
    8. Gerald Schwank
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work examines a role for altered splicing in pancreatic tumorigenesis by interrogating effects of a specific mutation in the Sf3b splicing factor in pancreatic organoid and cell line growth primarily, with some in vivo work also performed. There is significant potential in the study but there is a concern about the lack of in vivo validation of claims that are most relevant to metastatic progression and the focus on one specific mechanism at the expense of other possible effects on splicing of factors important for disease progression.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity