Pharmacology and Toxicology
A list by eLife
Pharmacology and Toxicology articles that have been evaluated by eLife.
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Local Generation and Efficient Evaluation of Numerous Drug Combinations in a Single Sample
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A generic binding pocket for small molecule I Ks activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes
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The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational in vitro study
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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
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Population Dynamics of Immunological Synapse Formation Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Treatment Resistance
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A mechanism of uncompetitive inhibition of the serotonin transporter
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Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals
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Modeling osteoporosis to design and optimize pharmacologic therapies comprising multiple drug types
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Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model
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Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation
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A Single Multipurpose FSH–Blocking Therapeutic for Osteoporosis and Obesity
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Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
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Common coupling map advances GPCR-G protein selectivity
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NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of-Function Mice, and Wild-Type Mice and Rats
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Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands
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Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy
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μ-Theraphotoxin-Pn3a inhibition of Ca V 3.3 channels reveals a novel isoform-selective drug binding site
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Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in Strongyloides stercoralis
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Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice
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Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis
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