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  1. The MODY-associated TALK-1 L114P mutation causes islet α-cell overactivity and β-cell inactivity resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

    This article has 8 authors:
    1. Arya Y. Nakhe
    2. Prasanna K. Dadi
    3. Jinsun Kim
    4. Shristi Shrestha
    5. Jean-Philippe Cartailler
    6. Leesa Sampson
    7. Mark A. Magnuson
    8. David A. Jacobson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This article studies how a human mutation in a specific potassium channel causes altered islet cell function and monogenic diabetes. The work uses CRISPR-engineered mice to show that the gain-of-function mutation causes increased potassium flux, reduced insulin secretion, and impaired glucose tolerance. The convincing data substantially support the conclusions, and the work is important for understanding islet cell function and glucose homeostasis.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

    This article has 2 authors:
    1. Yunlu Xue
    2. Constance L. Cepko
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study advances our understanding of the cell specific treatment of cone photoreceptor degeneration by Txnip. The evidence supporting the conclusions is convincing with rigorous genetic manipulation of Txnip mutations, however, there are a few areas in which the article may be improved through further analysis and application of the data. The work will be of broad interest to vision researchers, cell biologists and biochemists.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  3. A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

    This article has 9 authors:
    1. Gonzalo Hernandez-Hernandez
    2. Samantha C. O’Dwyer
    3. Collin Matsumoto
    4. Mindy Tieu
    5. Zhihui Fong
    6. Pei-Chi Yang
    7. Timothy J. Lewis
    8. L. Fernando Santana
    9. Colleen E. Clancy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study combines experiments and theory to develop a sex-based in silico model of arterial myocytes. The ionic currents of the model and its sex difference based on experimental data and comparisons of model properties with experimental data at the single cell and tissue scale are convincing. If the rigor used to assess the model (specifically the simplicity of the 1D vessel model) was improved, and there was an addition of quantitative analysis of the data examining similarity between male/female experimental/simulation, the paper would be improved.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. Septin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function

    This article has 12 authors:
    1. Rita De Gasperi
    2. Laszlo Csernoch
    3. Beatrix Dienes
    4. Monika Gonczi
    5. Jayanta K. Chakrabarty
    6. Shahar Goeta
    7. Abdurrahman Aslan
    8. Carlos A. Toro
    9. David Karasik
    10. Lewis M. Brown
    11. Marco Brotto
    12. Christopher P. Cardozo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This convincing study demonstrates a potentially important role for the factor Numb in skeletal muscle excitation-contraction coupling. Numb knockout reduced contractile force. The authors thus demonstrate a novel role for Numb in calcium release in skeletal muscle.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  5. Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

    This article has 3 authors:
    1. Priyanka Das
    2. Alejandro Aballay
    3. Jogender Singh
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study has the potential to reveal insights into how calcineurin influences C. elegans lifespan through its role in controlling the defecation motor program. Currently, the evidence in support of the conclusions is still incomplete, largely due to concerns about partial gene inactivation by RNAi. The inclusion of experiments using a tax-6 null allele would mitigate these concerns.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  6. Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

    This article has 3 authors:
    1. Priyanka Das
    2. Alejandro Aballay
    3. Jogender Singh
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study has the potential to reveal insights into how calcineurin influences C. elegans lifespan through its role in controlling the defecation motor program. Currently, the evidence in support of the conclusions is still incomplete, largely due to concerns about partial gene inactivation by RNAi. The inclusion of experiments using a tax-6 null allele would mitigate these concerns.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  7. Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

    This article has 6 authors:
    1. Xinle Zou
    2. Sri Karthika Shanmugam
    3. Scott A. Kanner
    4. Kevin J. Sampson
    5. Robert S. Kass
    6. Henry M. Colecraft
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides a substantial advance with a method by which a protein target resistant to therapeutic approaches can be uniquely modulated by a cellular protein kinase ferried by nanobodies to a precise molecular site of recruitment. Evidence for this major claim is compelling, but evidence for some of the minor claims seems incomplete. The work will be of broad interest to cell biologists, cardiovascular researchers, and drug developers.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  8. Leveraging genetic correlation structure to target discrete signaling mechanisms across metabolic tissues

    This article has 23 authors:
    1. Mingqi Zhou
    2. Cassandra Van
    3. Jeffrey Molendijk
    4. Ivan Yao-Yi Chang
    5. Casey Johnson
    6. Leandro M. Velez
    7. Reichelle X. Yeo
    8. Hosung Bae
    9. Johnny Le
    10. Natalie Larson
    11. Ron Pulido
    12. Carlos H V Nascimento-Filho
    13. Andrea Hevener
    14. Lauren M. Sparks
    15. Jaime N. Justice
    16. Erin E. Kershaw
    17. Ivan Marazzi
    18. Nicholas Pannunzio
    19. Dequina Nicholas
    20. Benjamin Parker
    21. Cholsoon Jang
    22. Selma Masri
    23. Marcus Seldin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The tool developed and implemented in this study has valuable significance for the combined analysis of large, diverse omics datasets, but some of the methodology is incomplete. Regarding the strength of evidence, there are some more significant concerns regarding potentially inadequate controls for false discovery and multiple testing corrections.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  9. Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts

    This article has 5 authors:
    1. Pooja Joshi
    2. Shanea Estes
    3. Deeptankar DeMazumder
    4. Bjorn C. Knollmann
    5. Swati Dey
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study examined the use of dantrolene, a Ryanodine Receptor stabilizer, in slowing pathological progression of pressure-overload heart failure in a guinea pig model and reducing arrhythmias. The data were collected and analyzed using solid and validated methodology and can be used as a starting point for future studies of dantrolene in Ca2+ handling in ROS production and further deterioration of cardiac function in chronic heart failure.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  10. Molecular tuning of sea anemone stinging

    This article has 8 authors:
    1. Lily S He
    2. Yujia Qi
    3. Corey AH Allard
    4. Wendy A Valencia-Montoya
    5. Stephanie P Krueger
    6. Keiko Weir
    7. Agnese Seminara
    8. Nicholas W Bellono
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important paper that links distinctive stinging behavior of two related anemones occupying different ecological niches to varying inactivation properties of voltage-gated calcium channels conferred by auxiliary Cavβ subunits. Further convincing evidence is provided that these differences are mediated by alternative splicing of Cavβ subunit of the calcium channel. The study will be of interest to scientists studying Ca2+ signaling, ion channel biophysicists, and marine biologists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  11. Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver

    This article has 7 authors:
    1. Keshav Thapa
    2. James J. Kadiri
    3. Karla Saukkonen
    4. Iida Pennanen
    5. Minying Cai
    6. Eriika Savontaus
    7. Petteri Rinne
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The significance of this manuscript is that is provides useful information for the field of hepatology and endocrinology on the regulatory mechanisms of cholesterol homeostasis by melanocortin. The authors provide solid evidence utilizing both in vivo and in vitro molecular, cellular, and biochemical approaches to support their claims.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  12. Mechanistic insights into robust cardiac I Ks potassium channel activation by aromatic polyunsaturated fatty acid analogues

    This article has 5 authors:
    1. Briana M. Bohannon
    2. Jessica J. Jowais
    3. Leif Nyberg
    4. Sara I. Liin
    5. H. Peter Larsson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work reports important findings regarding the regulation of ion channels by polyunsaturated fatty acids (PUFAs) through the identification of novel aromatic PUFA analogs with potent effects on the IKs channels, which allow for mechanistic insights into their mode of action. The experiments are solid, combining site-directed mutagenesis, electrophysiological and pharmacological approaches to dissect the different molecular mechanisms and sites involved in the functional interactions. This work will be of broad interest to ion channel biophysicists, physiologists, and medical chemists interested in drug development for LQT syndrome. The study presents some limitations that may need to be addressed or further discussed, in order to strengthen the conclusions reached in the study.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  13. A rapid microglial metabolic response controls metabolism and improves memory

    This article has 20 authors:
    1. Anne Drougard
    2. Eric H Ma
    3. Vanessa Wegert
    4. Ryan Sheldon
    5. Ilaria Panzeri
    6. Naman Vatsa
    7. Stefanos Apostle
    8. Luca Fagnocchi
    9. Judith Schaf
    10. Klaus Gossens
    11. Josephine Völker
    12. Shengru Pang
    13. Anna Bremser
    14. Erez Dror
    15. Francesca Giacona
    16. Sagar
    17. Michael X Henderson
    18. Marco Prinz
    19. Russell G Jones
    20. J. Andrew Pospisilik
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study demonstrates a link between an acute high fat diet, microglial metabolism and improved higher cognitive function. The evidence supporting the proposed model is incomplete at this stage and would benefit from additional experiments probing the link between microglial metabolism and higher cognitive function. Following more mechanistic dissection, this work will be of interest to a broad audience in the field of neuroscience, metabolism, and immunology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  14. High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen

    This article has 9 authors:
    1. Wan-ping Yang
    2. Mei-qi Li
    3. Jie Ding
    4. Jia-yan Li
    5. Gang Wu
    6. Bao Liu
    7. Yu-qi Gao
    8. Guo-hua Wang
    9. Qian-qian Luo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors set out to study the development of high altitude polycythemia, which affects mice in a hypoxia chamber and humans staying at a hypoxic atmosphere at high altitude. The findings are useful both for initiating the discussion of the hypothesis that splenic red pulp macrophages, central to red cell survival, are impacted by hypoxia, and for providing some data that partially supports this hypothesis. However, the current data are inadequate to fully support the authors' conclusions that RPM are inefficient during hypoxia, reducing erythrophagocytosis, and new data provides evidence of the opposite conclusion, given that RBC lifespan is decreased (rather than increased) in response to hypoxia, suggesting that RPM are more efficient at erythrophagocytosis.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 2 listsLatest version Latest activity
  15. Calcium and Bicarbonate Signaling Pathways have Pivotal, Resonating Roles in Matching ATP Production to Demand

    This article has 7 authors:
    1. Maura Greiser
    2. Mariusz Karbowski
    3. Aaron D. Kaplan
    4. Andrew K. Coleman
    5. Carmen A. Mannella
    6. W. J. Lederer
    7. Liron Boyman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The important work presented here provides findings that substantially advance our understanding of a major research question into how bicarbonate/CO2 signaling regulates cardiac mitochondrial energy supply. The methods, data, and analyses broadly support the claims with only minor weaknesses concerning the exact spatial location of the enzymes involved. The work will be of broad interest to cell biologists and biochemists interested in metabolic control.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  16. Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

    This article has 8 authors:
    1. Chandramohan Chitraju
    2. Alexander W. Fischer
    3. Yohannes A. Ambaw
    4. Kun Wang
    5. Bo Yuan
    6. Sheng Hui
    7. Tobias C. Walther
    8. Robert V. Farese
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment:

      This study introduces a valuable paradigm in the field of adipose tissue biology: blocking triglyceride storage in adipose tissue does not lead to lipodystrophy and impaired glucose homeostasis but instead improves metabolic health. The evidence supporting these claims is convincing, based on a comprehensive metabolic analysis, although mechanistic studies would strengthen the study and its impact. This study will be of high interest to those in the adipose tissue biology and metabolism fields.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  17. VO 2max prediction based on submaximal cardiorespiratory relationships and body composition in male runners and cyclists: a population study

    This article has 7 authors:
    1. Szczepan Wiecha
    2. Przemysław Seweryn Kasiak
    3. Piotr Szwed
    4. Tomasz Kowalski
    5. Igor Cieśliński
    6. Marek Postuła
    7. Andrzej Klusiewicz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors have established new formulas to predict maximum oxygen uptake for cyclists and runners based on submaximal exercise testing and anthropometric characteristics. This is an important study with a large and comprehensive dataset, which may be helpful for many exercise labs. The work is convincing, using appropriate and validated methodology in line with the current state-of-the-art, as shown by references to common exercise books.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  18. Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

    This article has 7 authors:
    1. Erin J. Ciampa
    2. Padraich Flahardy
    3. Harini Srinivasan
    4. Christopher Jacobs
    5. Linus Tsai
    6. S. Ananth Karumanchi
    7. Samir M. Parikh
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study provides insights into mechanisms of placental aging and its relationship to labor initiation. The authors provide solid evidence and have thoroughly investigated the molecular characteristics of normal placental aging using in vivo and in vitro model systems and human placental tissue analysis to corroborate their findings. This work contributes to existing work in placental aging and preterm birth and will be of interest to reproductive scientists.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 3 listsLatest version Latest activity
  19. Hypermetabolism in mice carrying a near complete human chromosome 21

    This article has 12 authors:
    1. Dylan C. Sarver
    2. Cheng Xu
    3. Susana Rodriguez
    4. Susan Aja
    5. Andrew E. Jaffe
    6. Feng J. Gao
    7. Michael Delannoy
    8. Muthu Periasamy
    9. Yasuhiro Kazuki
    10. Mitsuo Oshimura
    11. Roger H. Reeves
    12. G. William Wong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important paper provides new insight into the effect of extra-copies of a chromosome, thus aneuploidy, on body metabolisms in mammals. The authors used various solid analyses on the metabolisms and physiology of the transgenic mouse with most of human chromosome 21 and presented convincing results to support the authors' claims. The work would be of interest to researchers who work on the physiology and biochemistry of body metabolisms in mammals.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  20. An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

    This article has 24 authors:
    1. Luyang Cao
    2. Lixiang Ma
    3. Juan Zhao
    4. Xiangyu Wang
    5. Xinzou Fan
    6. Wei Li
    7. Yawen Qi
    8. Yingkui Tang
    9. Jieya Liu
    10. Shengxian Peng
    11. Li Yang
    12. Liangxue Zhou
    13. Li Li
    14. Xiaobo Hu
    15. Yuan Ji
    16. Yingyong Hou
    17. Yi Zhao
    18. Xianming Zhang
    19. Youyang Zhao
    20. Yong Zhao
    21. Yuquan Wei
    22. Asrar B. Malik
    23. Hexige Saiyin
    24. Jingsong Xu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper reports the fundamental discovery of a new function of neutrophil in specifically clearing apoptotic hepatocytes by penetrating the cells rather than engulfing them without causing inflammation as a part of tissue homeostasis. This solid study transforms the way we think about role of neutrophil in pathogenesis of autoimmune liver disease.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity