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  1. Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

    This article has 3 authors:
    1. Sergio Casas-Tintó
    2. Nuria García-Guillen
    3. Maria Losada-Pérez
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this work, the authors use a Drosophila adult ventral nerve cord injury model extending and confirming previous observations; this important study reveals key aspects of adult neural plasticity. Taking advantage of several genetic reporter and fate tracing tools, the authors provide solid evidence for different forms of glial plasticity, that are increased upon injury. The data on detected plasticity under physiologic conditions and especially the extent of cell divisions and cell fate changes upon injury would benefit from validation by additional markers. The experimental part would improve if strengthened and accompanied by a more comprehensive integration of results regarding glial reactivity in the adult CNS.

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    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  2. PVN-mPFC OT projections modulates pup-directed pup care or attacking in virgin mandarin voles

    This article has 12 authors:
    1. Lu Li
    2. Zhixiong He
    3. Yin Li
    4. Caihong Huang
    5. Wenjuan Hou
    6. Zijian Lv
    7. Lizi Zhang
    8. Yishan Qu
    9. Yahan Sun
    10. Kaizhe Huang
    11. Xiao Han
    12. Fadao Tai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work provides insights into the neural mechanisms regulating specific parental behaviors. By identifying a key role for oxytocin synthesizing cells in the paraventricular nucleus of the hypothalamus and their projections to the medial prefrontal cortex in promoting pup care and inhibiting infanticide, the study advances our understanding of the neurobiological basis of these contrasting behaviors in male and female mandarin voles. The evidence supporting the authors' conclusions is solid but lacks some critical methodological detail. The work should be of interest to researchers studying neuropeptide control of social behaviors in the brain.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  3. Chronic activation of a negative engram induces behavioral and cellular abnormalities

    This article has 9 authors:
    1. Alexandra L. Jellinger
    2. Rebecca L. Suthard
    3. Bingbing Yuan
    4. Michelle Surets
    5. Evan A. Ruesch
    6. Albit J. Caban
    7. Shawn Liu
    8. Monika Shpokayte
    9. Steve Ramirez
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study reports the behavioural and physiological effects of the longitudinal activation of neurons associated with negative experiences. The main claims of the paper are supported by solid experimental evidence, but the specificity of the long-term manipulation requires additional validation. This study will be of interest to neuroscientists working on memory.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings

    This article has 3 authors:
    1. Proloy Das
    2. Mingjian He
    3. Patrick L. Purdon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This method paper proposes a valuable Oscillation Component Analysis (OCA) approach, in analogy to Independent Component Analysis (ICA), in which source separation is achieved through biophysically inspired generative modeling of neural oscillations. The empirical evidence justifying the approach's advantage is incomplete. This work will be of interest to cognitive neuroscience, neural oscillation, and MEG/EEG.

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    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  5. Associative plasticity of granule cell inputs to cerebellar Purkinje cells

    This article has 2 authors:
    1. Rossella Conti
    2. Céline Auger
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents useful findings on an unresolved question of cerebellar physiology: Do synapses between Purkinje cells and granule cells, made by the ascending part of the granule cells' axon, have different properties than those made by parallel fibers? The authors conducted patch-clamp recordings on rat cerebellar slices and found a new type of plasticity in the synapses of the ascending part of granule cell axons. While the finding may contribute to a better understanding of cerebellar function, the results are still incomplete because the shift in the baseline recording may have influenced the readout of long-term plasticity.

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    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  6. Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury

    This article has 10 authors:
    1. Qing Zhao
    2. Yanjing Zhu
    3. Yilong Ren
    4. Lijuan Zhao
    5. Jingwei Zhao
    6. Shuai Yin
    7. Haofei Ni
    8. Rongrong Zhu
    9. Liming Cheng
    10. Ning Xie
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study demonstrated that ablation of astrocytes in the lumbar spinal cord not only reduced neuropathic pain but also caused microglia activation. The findings presented add considerable value to the current understanding of the role of astrocyte elimination in neuropathic pain, offering convincing evidence that supports existing hypotheses and insights into the interactions between astrocytes and microglial cells, likely through IFN-mediated mechanisms. This study may also offer a new therapeutic strategy for the treatment of debilitating neuropathic pain in patients with SCI.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  7. Age-Related Decline in BBB Function is More Pronounced in Males than Females

    This article has 16 authors:
    1. Xingfeng Shao
    2. Qinyang Shou
    3. Kimberly Felix
    4. Brandon Ojogho
    5. Xuejuan Jiang
    6. Brian T. Gold
    7. Megan M Herting
    8. Eric L Goldwaser
    9. Peter Kochunov
    10. L. Elliot Hong
    11. Ioannis Pappas
    12. Meredith Braskie
    13. Hosung Kim
    14. Steven Cen
    15. Kay Jann
    16. Danny JJ Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding that the blood-brain barrier functionality changes with age and differs between males and females. The analysis is solid, comprising a large and racially diverse dataset, and utilizes a contrast-agent-free MRI method. Since limited work has been done in the MRI field on the blood-brain barrier using this method, this study is of great interest to neuroimaging researchers and clinicians.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  8. Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity

    This article has 2 authors:
    1. Toshitake Asabuki
    2. Claudia Clopath
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important study that investigates how neural networks can learn to stochastically replay presented sequences of activity according to learned transition probabilities. The authors use error-based excitatory plasticity to minimize the difference between internally predicted activity and stimulus-driven activity, and inhibitory plasticity to maintain E-I balance. The approach is solid but the choice of learning rules and parameters is not always always justified, lacking a formal derivation and concrete experimental predictions.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  9. In mice, discrete odors can selectively promote the neurogenesis of sensory neuron subtypes that they stimulate

    This article has 3 authors:
    1. Kawsar Hossain
    2. Madeline Smith
    3. Stephen W. Santoro
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings relevant to research on olfactory neurogenesis and long-term adaptation. The evidence, at this stage, is incomplete. First, the effects described could, in part, also be attributed to "downregulation" of OR subtype-specific neurogenesis upon sensory deprivation, instead of selectively increased neurogenesis. Second, additional control experiments would be needed to support the main claims and rule out alternative explanations.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  10. Cardiac afferent signals can facilitate visual dominance in binocular rivalry

    This article has 3 authors:
    1. John P. Veillette
    2. Fan Gao
    3. Howard C. Nusbaum
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a binocular rivalry study that uses ECG to present visual stimuli pulsing in line with cardiac events, to examine whether systole-entrained stimuli (i.e. presented during the period where the heart has contracted) are suppressed within visual awareness. Arguably out of line with this idea, the dominance durations were increased for systole-entrained stimuli. The manuscript addresses an important, precisely defined, and theoretically well-motivated question using sophisticated experimental and statistical methods. The interpretation of these results is not straightforward, however, such that they currently only provide incomplete support for the claims.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  11. Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

    This article has 8 authors:
    1. Minsik Yun
    2. Do-Hyoung Kim
    3. Tal Soo Ha
    4. Kang-Min Lee
    5. Eungyu Park
    6. Markus Knaden
    7. Bill S. Hansson
    8. Young-Joon Kim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental work unravels how female Drosophila can assess their social context via chemosensory cues and modulate the sperm storage process after copulation accordingly. A convincing set of rigorous experiments uncovers specific pheromones that influence the excitability of the female brain receptivity circuit and their propensity to discard inseminate from a mating. This insight into neuronal mechanisms of sexual behavior plasticity is of general interest to scientists working in the fields of animal behavior, neuroscience, evolution, and sexual selection, as well as insect chemosensation and reproduction.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  12. Modeling Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids using microglia-sufficient brain organoids

    This article has 13 authors:
    1. Wei Jie Wong
    2. Yi Wen Zhu
    3. Hai Ting Wang
    4. Jia Wen Qian
    5. Ziyi Li
    6. Li Song
    7. Zhao Yuan Liu
    8. Wei Guo
    9. Shuang Yan Zhang
    10. Bing Su
    11. Fang Ping He
    12. Kang Wang
    13. Florent Ginhoux
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study sheds light on the mechanisms underlying a rare brain disease, offering insight into the role of microglia in this complex pathophysiology. The evidence presented is solid, utilizing state-of-the-art laboratory models to explore cellular interactions and disease development. While further research is needed, this study will be of interest to neuroscientists and clinicians aiming to understand and combat similar neurodegenerative disorders.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  13. Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

    This article has 6 authors:
    1. Yuqi Cai
    2. Zhirong Zhao
    3. Mingyue Shi
    4. Mingfang Zheng
    5. Ling Gong
    6. Miao He
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this study, the authors provide valuable evidence that the LGE is not a significant source of oligodendrocytes for the cortex. The reviewers did find some technical considerations that call for some modulation of the strength of the authors' conclusions and also pointed out some aspects of the data that were incomplete as presented.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  14. LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton

    This article has 21 authors:
    1. Giulia Tombesi
    2. Shiva Kompella
    3. Giulia Favetta
    4. Chuyu Chen
    5. Yibo Zhao
    6. Martina Sevegnani
    7. Antonella Marte
    8. Ilaria Battisti
    9. Ester Morosin
    10. Marta Ornaghi
    11. Lucia Iannotta
    12. Nicoletta Plotegher
    13. Laura Civiero
    14. Franco Onofri
    15. Britta J Eickholt
    16. Giovanni Piccoli
    17. Giorgio Arrigoni
    18. Dayne Beccano-Kelly
    19. Claudia Manzoni
    20. Loukia Parisiadou
    21. Elisa Greggio
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study further discloses the function of LRRK2 in BDNF-dependent synaptic processes in identifying postsynaptic actin cytoskeleton as a convergent site of LRRK2 pathophysiological activity. Multiple approaches in different cellular models provide mostly solid (but at times preliminary) evidence to support (many) of the conclusions, overall consistent with bioinformatics analyses covering previously published work. While an exciting start that should be pursued, examples are suggested by reviewers to add in additional experimentation to better support the expansive interpretation. The identification of mechanisms of LRRK2 action at the synapse is considered highly significant, as better knowledge in this regard may provide insight into why dopaminergic cells die with over-active LRRK2.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  15. Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

    This article has 8 authors:
    1. Katrina Bartas
    2. May Hui
    3. Pieter Derdeyn
    4. Guilian Tian
    5. Jose J. Vasquez
    6. Ghalia Azouz
    7. Cindy M. Yamamoto
    8. Kevin T. Beier
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study by Bartas and colleagues examined how patterns of monosynaptic input to specific cell types in the ventral tegmental area are altered by drugs of abuse. The authors applied a dimensionality reduction approach (principal component analysis) and showed that various drugs of abuse, and somewhat surprisingly the anesthesia alone (ketamine/xylasin), caused changes in the distribution of inputs labeled by the transsynaptic rabies virus. While there are some issues to be addressed, the evidence supporting the conclusions is overall solid, and provides information that is of value to the field, as well as a cautionary note on the interpretation of rabies virus-based tracing experiments.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  16. Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

    This article has 7 authors:
    1. Felix Michaud
    2. Ruggiero Francavilla
    3. Dimitry Topolnik
    4. Parisa Iloun
    5. Suhel Tamboli
    6. Frederic Calon
    7. Lisa Topolnik
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study describes important findings related to early disruptions in disinhibitory modulation exerted by VIP+ interneurons, in CA1 in a transgenic model of Alzheimer's disease pathology. The authors provide a convincing analysis at the cellular, synaptic, network, and behavioral levels on how these changes correlate and might be related to behavioral impairments during these early stages of AD pathology.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  17. Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species

    This article has 16 authors:
    1. Hans Martin Kjer
    2. Mariam Andersson
    3. Yi He
    4. Alexandra Pacureanu
    5. Alessandro Daducci
    6. Marco Pizzolato
    7. Tim Salditt
    8. Anna-Lena Robisch
    9. Marina Eckermann
    10. Mareike Toepperwien
    11. Anders Bjorholm Dahl
    12. Maria Louise Elkjær
    13. Zsolt Illes
    14. Maurice Ptito
    15. Vedrana Andersen Dahl
    16. Tim B. Dyrby
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study presents new observations on white matter organisation at the micron scale, using a combination of synchrotron imaging and diffusion MRI across two species. Notably, the authors provide solid evidence for the fasciculation of axons within major fibre bundles into laminar structures, though these structures are not consistently observed across modalities or species. The study will be of general interest to neuroanatomists and those interested in white matter imaging.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  18. The ketone body ő≤-hydroxybutyrate rescues neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

    This article has 4 authors:
    1. Sebasti√°n Giunti
    2. María Gabriela Blanco
    3. María José De Rosa
    4. Diego Rayes
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study convincingly demonstrates the ability of reverting a neurodevelopmental defect with a dietary intervention. While the exact mechanisms remain to be elucidated, the authors establish a simple but important system to study the PI3K/Akt/FOXO pathway but also the action of ketone bodies and their potential therapeutic use. This study will be of particular interest to the large community of scientists studying E/I disequilibrium in the nervous system.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  19. Mining the neuroimaging literature

    This article has 5 authors:
    1. J√©r√īme Dock√®s
    2. Kendra Oudyk
    3. Mohammad Torabi
    4. Alejandro I de la Vega
    5. Jean-Baptiste Poline
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents an important ecosystem designed to support literature mining in biomedical research, showcasing a methodological framework that includes tools like Pubget for article collection and labelbuddy for text annotation. The solid evidence presented for these tools suggests they could streamline the analysis and annotation of scientific literature, potentially benefiting research across a range of biomedical disciplines. While the primary focus is on neuroimaging literature, the applicability of these methods and tools might extend further, offering useful advancements in the practices of meta-research and literature mining.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  20. Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

    This article has 6 authors:
    1. MinHyuk Lee
    2. Se Hoon Park
    3. Kyeung Min Joo
    4. Jae Young Kwon
    5. Kyung-Hoon Lee
    6. KyeongJin Kang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study provides new insight into how non-synaptic interactions affect the activity of adjacent gustatory neurons housed within the same sensillum. The electrophysiological, behavioral, and genetic data supporting the study's conclusions are solid, although the inclusion of additional control experiments would strengthen the study. This work will be of interest to neuroscientists studying chemosensory processing or regulation of neuronal excitability.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity