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  1. Rediscovering the Rete Ovarii : a secreting auxiliary structure to the ovary

    This article has 5 authors:
    1. Dilara N. Anbarci
    2. Jennifer McKey
    3. Daniel S. Levic
    4. Michel Bagnat
    5. Blanche Capel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports the developmental dynamics and molecular markers of the rete ovarii during ovarian development. However, the data supporting the main conclusions remain incomplete. This study will be of interest to developmental and reproductive biologists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

    This article has 22 authors:
    1. Rion Brattig Correia
    2. Joana M. Almeida
    3. Margot J. Wyrwoll
    4. Irene Julca
    5. Daniel Sobral
    6. Chandra Shekhar Misra
    7. Sara Di Persio
    8. Leonardo G. Guilgur
    9. Hans-Christian Schuppe
    10. Neide Silva
    11. Pedro PrudĂŞncio
    12. Ana NĂłvoa
    13. Ana S. Leocádio
    14. Joana Bom
    15. Sandra Laurentino
    16. Moisés Mallo
    17. Sabine Kliesch
    18. Marek Mutwil
    19. Luis M. Rocha
    20. Frank TĂĽttelmann
    21. Jörg D. Becker
    22. Paulo Navarro-Costa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports the deep evolutionary conservation of a core genetic program regulating spermatogenesis in flies, mice, and humans. The data presented are supportive of the main conclusion and generally convincing. This work will be of interest to evolutionary and reproductive biologists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  3. Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone

    This article has 7 authors:
    1. Yan-Xue Li
    2. Xin-Le Kang
    3. Yan-Li Li
    4. Xiao-Pei Wang
    5. Qiao Yan
    6. Jin-Xing Wang
    7. Xiao-Fan Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this important study, Li and others identified cell membrane receptors for juvenile hormone (JH), a terpenoid hormone in insects that regulates their development and reproduction. While intracellular receptors for JH have been well characterized, membrane receptors for JH have remained elusive. Although the authors provide convincing evidence to indicate that the receptor tyrosine kinases they identified bind to JH in vitro and induce responses in cultured cells, their loss-of-function phenotypes are not consistent with known JH functions, leaving obscure the physiological roles of these receptors in mediating in vivo JH function.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. Cytoneme-mediated intercellular signaling in keratinocytes essential for epidermal remodeling

    This article has 5 authors:
    1. Yi Wang
    2. Qingan He
    3. Oliver Has
    4. Kiarash Forouzesh
    5. Dae Seok Eom
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable evidence that differentiated cells of the zebrafish skin form membrane protrusions called cytonemes, that contact and potentially transmit Notch signals to cells of the intermediate layer below. Evidence that periderm cells send out cytoneme-like protrusions is solid, and perturbations that affect cytoneme number clearly affect periderm structure and gene expression. However, evidence that these effects are directly due to cytoneme mediated-Notch signaling is incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  5. Astrogliosis and Neuroinflammation Underlie Scoliosis Upon Cilia Dysfunction

    This article has 17 authors:
    1. Morgane Djebar
    2. Isabelle Anselme
    3. Guillaume Pezeron
    4. Pierre-Luc Bardet
    5. Yasmine Cantaut-Belarif
    6. Alexis Eschstruth
    7. Diego LĂłpez Santos
    8. Hélène Le Ribeuz
    9. Arnim Jenett
    10. Hanane Khoury
    11. Joelle VĂ©ziers
    12. Caroline Parmentier
    13. Aurélie Hirschler
    14. Christine Carapito
    15. Ruxandra Bachmann-Gagescu
    16. Sylvie Schneider-Maunoury
    17. Christine Vesque
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study analyzes the role of the ciliary transition zone protein rpgrip1l in the development of the scoliotic phenotype in zebrafish. Through convincing proteomic and experimental validation in vivo, the authors demonstrated increased Annexin A2 expression in the brain and increased LCP1+ immune cell infiltration in scoliosis fish. These findings provide additional evidence for the previously proposed role of neuroinflammation in the development of idiopathic scoliosis in zebrafish.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  6. Non-autonomous cell redox-pairs dictate niche homeostasis in multi-lineage stem populations

    This article has 4 authors:
    1. Olivia Majhi
    2. Aishwarya Chhatre
    3. Tanvi Chaudhary
    4. Devanjan Sinha
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work focuses on the role of Reactive Oxygen Species (ROS) signaling in cyst stem cells of the Drosophila testis. In particular, the authors suggest that ROS can act as signaling molecules between somatic and germ stem cells of the testis. The work is potentially useful, although the evidence that supports the authors' claims is incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  7. Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    This article has 7 authors:
    1. Adriana Karina Alexander
    2. Karina F Rodriguez
    3. Yu-Ying Chen
    4. Ciro Amato
    5. Martin A Estermann
    6. Xin Xu
    7. Humphrey Yao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). Solid data generally support the main conclusions. However, data presentation and interpretation need improvement for clarity and accuracy. The study will be of interest to developmental and reproductive biologists, as well as andrologists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  8. Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

    This article has 9 authors:
    1. Emily Delgouffe
    2. Samuel Madureira Silva
    3. Frédéric Chalmel
    4. Wilfried Cools
    5. Camille Raets
    6. Kelly Tilleman
    7. Guy T’Sjoen
    8. Yoni Baert
    9. Ellen Goossens
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents new knowledge of the spermatogonial stem cell (SSC) niche in trans women after gender-affirming hormone therapy (GAHT). While the evidence supporting the claims is convincing, weaknesses identified by both reviewers should be addressed. The work will be of interest to researchers and clinicians working in the field of sexual medicine and andrology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  9. Loss of ninein interferes with osteoclast formation and causes premature ossification

    This article has 11 authors:
    1. Thierry Gilbert
    2. Merlin Barbier
    3. Benjamin Duployer
    4. Ophélie Dufrançais
    5. Laure-Elene Martet
    6. Elisa Dalbard
    7. Loelia Segot
    8. Christophe Tenailleau
    9. Christel VĂ©rollet
    10. Christiane Bierkamp
    11. Andreas Merdes
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study offers new insight into the role of centrosome protein ninein in skeletal development through an analysis of the skeletal phenotype of ninein-deficient mice. While there is solid evidence supporting the conclusion that the absence of ninein leads to transient skeletal abnormalities and a lasting reduction in osteoclastogenesis, the evidence to substantiate the claim that enhanced ossification is attributed to reduced osteoclast formation/activity is insufficient. This work will be of interest to scientists in bone biology and skeletal development field.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  10. Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

    This article has 20 authors:
    1. Alexandra V. Bruter
    2. Ekaterina A. Varlamova
    3. Nina I. Stavskaya
    4. Zoia G. Antysheva
    5. Vasily N. Manskikh
    6. Anna V. Tvorogova
    7. D. S. Korshunova
    8. Alvina I. Khamidullina
    9. Marina V. Utkina
    10. Viktor P. Bogdanov
    11. Alyona I. Nikiforova
    12. Eugene A. Albert
    13. Denis O. Maksimov
    14. Jing Li
    15. Mengqian Chen
    16. Alexander A. Shtil
    17. Igor B. Roninson
    18. Vladislav A. Mogila
    19. Yulia Y. Silaeva
    20. Victor V. Tatarskiy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study reports an unexpected phenotype of atrophy of the male reproductive system and infertility upon combined knockout in adult mice of the genes encoding the two kinases CDK8 and CDK19. While the morphological evidence and single-cell transcriptomic data are solid, the proposed mechanism remains unconvincing as there is little evidence for causality, and some controls are missing. This work will be of interest to reproductive biologists, developmental biologists, and andrologists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  11. Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

    This article has 5 authors:
    1. Denise M. Poltavski
    2. Alexander T. Cunha
    3. Jaime Tan
    4. Henry M. Sucov
    5. Takako Makita
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable insights into our understanding of the development of the enteric nervous system. The authors use genetically engineered mice to study the behavior of stem cells in organizing the enteric nervous system and the secreted signals that regulate these cells. The study rests on a degree of incomplete evidence since the characterization of some of the mouse resources is not complete in the current version.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  12. Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity

    This article has 5 authors:
    1. Filip Knop
    2. Apolena Zounarová
    3. Vojtěch Šabata
    4. Teije Corneel Middelkoop
    5. Marie Macůrková
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study defines developmental roles for a protein kinase involved in endocytosis and reports a surprising finding that the kinase catalytic activity is unnecessary. However, several claims of the authors are only partially supported by the data. Although in its current form, this work is incomplete, it will be of broad interest to cell biologists and biochemists because this kinase was previously suggested to be a target of drug design efforts.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  13. Coordinated multiple cellular processes in tongue development

    This article has 23 authors:
    1. Maiko Kawasaki
    2. Katsushige Kawasaki
    3. Finsa Tisna Sari
    4. Takehisa Kudo
    5. Jun Nihara
    6. Madoka Kitamura
    7. Takahiro Nagai
    8. Vanessa Utama
    9. Yoko Ishida
    10. Fumiya Meguro
    11. Takayuki Nishimura
    12. Yuan Kogure
    13. Satoshi Maruyama
    14. Jun-ichi Tanuma
    15. Yoshito Kakihara
    16. Takeyasu Maeda
    17. Sarah Ghafoor
    18. Roman H. Khonsari
    19. Pierre Corre
    20. Paul T. Sharpe
    21. Martyn T. Cobourne
    22. Brunella Franco
    23. Atsushi Ohazama
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The investigation of the functional significance of the X-linked ciliary protein OFD1 gene in regulating the fate of cranial neural crest-derived cells (CNCCs) and its potential effect on myogenic progenitors during tongue development is interesting because the Ofd1 conditional knockout mouse model has a very striking phenotype and nicely mimics the phenotype in humans. It is a valuable model to understand human disease. This study will require additional experiments to support their conclusions.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  14. Obox4 promotes zygotic genome activation upon loss of Dux

    This article has 13 authors:
    1. Youjia Guo
    2. Tomohiro Kitano
    3. Kimiko Inoue
    4. Kensaku Murano
    5. Michiko Hirose
    6. Ten D. Li
    7. Akihiko Sakashita
    8. Hirotsugu Ishizu
    9. Narumi Ogonuki
    10. Shogo Matoba
    11. Masayuki Sato
    12. Atsuo Ogura
    13. Haruhiko Siomi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents an important finding that Obox4 and Dux act redundantly in regulating zygotic genome activation in mice. The evidence supporting the claims of the authors is solid. The work will be of interest to researchers interested in early embryo development and epigenetic reprogramming.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  15. IDENTIFICATION OF AN EARLY SUBSET OF CEREBELLAR NUCLEI NEURONS IN MICE

    This article has 8 authors:
    1. Maryam Rahimi-Balaei
    2. Shayan Amiri
    3. Thomas Lamonerie
    4. Sih-Rong Wu
    5. Huda Y. Zoghbi
    6. G. Giacomo Consalez
    7. Daniel Goldowitz
    8. Hassan Marzban
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors identify a population of neurons with a specific complement of markers that originate in a distinct location from where cerebellar nuclear precursor cells have been thought to originate, that show distinct developmental properties. The discovery of a new germinal zone giving rise to a new population of CN neurons is an important finding, and it enriches our understanding of cerebellar development. The claims are supported by solid evidence and the authors use a wide range of technical approaches, including transgenic mice, that allow them to disentangle the influence of distinct developmental organizers.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  16. The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability

    This article has 9 authors:
    1. Huishan Wang
    2. Xingyan Liu
    3. Yamin Liu
    4. Chencheng Yang
    5. Yaxin Ye
    6. Nengyin Sheng
    7. Shihua Zhang
    8. Bingyu Mao
    9. Pengcheng Ma
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study focuses on gene regulatory mechanisms essential for hindbrain development. Through molecular genetics and biochemistry, the authors propose a new mechanism for the control of Hox genes, which encode highly conserved transcription factors essential for hindbrain development. However, the strength of evidence is incomplete, as the main claims are only partially supported by the data. This work will be of interest to developmental biologists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  17. A microRNA that controls the emergence of embryonic movement

    This article has 4 authors:
    1. Jonathan A. C. Menzies
    2. Andre M. Chagas
    3. Tom Baden
    4. Claudio R. Alonso
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents a new quantitative imaging pipeline that describes with high temporal precision and throughput the movements of late-stage Drosophila embryos, a critical moment when motion first appears. A new approach is used to explore the role of miRNAs in motion onset and presents solid evidence that shows a role for miR-2b-1 and its target Janus in embryonic motion. The data are well supported but do not provide mechanistic insight into the emergence of movement while the writing inflates the importance of the conclusions. The authors must change the name of Janus which is already used in Drosophila genetics.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  18. Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition

    This article has 7 authors:
    1. Anastasiia Lozovska
    2. Ana NĂłvoa
    3. Ying-Yi Kuo
    4. Arnon D. Jurberg
    5. Gabriel G. Martins
    6. Anna-Katerina Hadjantonakis
    7. Moises Mallo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Morphological characteristics and phenotypes of mutations in key developmental genes suggest that head, trunk, and tail development are regulated by discernible modules. Gdf11 signalling plays a crucial role in orchestrating the transition from trunk to tail tissues in vertebrate embryos. This important study presents convincing evidence that Tgfbr1 acts upstream of Isl1 (a pivotal effector of Gdf11 signalling) and regulates blood vessels, the lateral plate mesoderm, and the endoderm associated with the trunk-to-tail transition. Together with the previous studies, this work identifies a key signal that acts as the pivot of the trunk-to-tail transition.

    Reviewed by eLife

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  19. TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

    This article has 13 authors:
    1. Jing Wang
    2. Yingying Yin
    3. Lei Yang
    4. Junchao Qin
    5. Zixiang Wang
    6. Chunhong Qiu
    7. Yuan Gao
    8. Gang Lu
    9. Fei Gao
    10. Zi-jiang Chen
    11. Xiyu Zhang
    12. Hongbin Liu
    13. Zhaojian Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study reports an important finding highlighting the essential role of the putative ion channel, TMC7 (transmembrane channel-like 7) in male fertility, thereby significantly advancing our understanding of the function of the previously uncharacterized protein in sperm development. The evidence supporting TMC7's requirement in acrosome biogenesis during spermatogenesis is solid, and its function as an ion channel requires more study.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  20. Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

    This article has 9 authors:
    1. Katsuyuki Nishi
    2. Taro Sakamaki
    3. Akiomi Nagasaka
    4. Kevin S. Kao
    5. Kay Sadaoka
    6. Masahide Asano
    7. Nobuyuki Yamamoto
    8. Akifumi Takaori-Kondo
    9. Masanori Miyanishi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript provides useful findings to further explore the heterogeneity of hematopoietic stem cells and myeloid-biased hematopoiesis during aging. The results presented in this study are incomplete and additional data is needed to strengthen the conclusions. Some of the methods and data analyses, including the replicates and statistical robustness, remain inadequate to support the primary claims.

    Reviewed by preLights, eLife

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity