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  1. Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: a population-based cohort study in UK Biobank

    This article has 7 authors:
    1. Yuchen Zhang
    2. Yitang Sun
    3. Qi Yu
    4. Suhang Song
    5. J. Thomas Brenna
    6. Ye Shen
    7. Kaixiong Ye
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important, well-conducted study in a large data set - the UK BioBank population - reports that both circulating omega-6 and omega-3 PUFAs as well as the ratio of omega-6 to omega-3 PUFAs are associated with lower all-cause, cancer and cardiovascular mortality. The study is convincing and these findings will be of broad interest to epidemiologists, nutritionists, medical practitioners and the general population.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. Design of the HPV-Automated Visual Evaluation (PAVE) Study: Validating a Novel Cervical Screening Strategy

    This article has 19 authors:
    1. Silvia de Sanjosé
    2. Rebecca B. Perkins
    3. Nicole G. Campos
    4. Federica Inturrisi
    5. Didem Egemen
    6. Brian Befano
    7. Ana Cecilia Rodriguez
    8. Jose JerĂłnimo
    9. Li C. Cheung
    10. Kanan Desai
    11. Paul Han
    12. Akiva P Novetsky
    13. Abigail Ukwuani
    14. Jenna Marcus
    15. Syed Rakin Ahmed
    16. Nicolas Wentzensen
    17. Jayashree Kalpathy-Cramer
    18. Mark Schiffman
    19. PAVE Study Group
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study will provide evidence about a novel screen-triage-treat strategy for cervical cancer prevention. The trial will generate convincing evidence regarding the efficacy, effectiveness, cost-effectiveness, feasibility and acceptability in a range of geographically spread low-resource settings. The strategy should contribute to improving access to cervical cancer prevention to vulnerable women with low access to health care, and, therefore, at the highest risk of cervical cancer.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 2 listsLatest version Latest activity
  3. Effect of an enhanced public health contact tracing intervention on the secondary transmission of SARS-CoV-2 in educational settings: the four-way decomposition analysis

    This article has 14 authors:
    1. Olivera Djuric
    2. Elisabetta Larosa
    3. Mariateresa Cassinadri
    4. Silvia Cilloni
    5. Eufemia Bisaccia
    6. Davide Pepe
    7. Laura Bonvicini
    8. Massimo Vicentini
    9. Francesco Venturelli
    10. Paolo Giorgi Rossi
    11. Patrizio Pezzotti
    12. Alberto Mateo Urdiales
    13. Emanuela Bedeschi
    14. the Reggio Emilia Covid-19 Working Group.
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides a potentially useful assessment of the effect of testing contacts of cases in school classes when identified, rather than at the end of quarantine, on both the number of secondary infections and other outcomes including tracing delay and identification of the possible source of infection. The authors find that the intervention likely led to a decrease in tracing delay and an increase in the number of possible sources of infection, though were unable to determine whether secondary transmission decreased, due in part to unmeasured confounding. While the surveillance system described provides a solid dataset appropriate for this analysis, the description of methods, study outcomes, and consideration of potential confounding factors is incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. A modelled analysis of the impact of COVID-19-related disruptions to HPV vaccination analysis

    This article has 6 authors:
    1. Louiza S Velentzis
    2. Megan A Smith
    3. James Killen
    4. Julia Brotherton
    5. Rebecca Guy
    6. Karen Canfell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents important findings for public health authorities and policymakers to enable them to make evidence-based decisions when deciding on how to manage the effect of HPV vaccination disruptions. This study is particularly relevant in light of the efforts of the WHO to achieve global elimination of cervical cancers. The findings are convincing and the model used is appropriate.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  5. Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic

    This article has 2 authors:
    1. K. Miriam Elfström
    2. Joakim Dillner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper is of interest to researchers and policy makers involved in cervical cancer prevention. The paper provides insight into how the Covid19 pandemic accelerated changes in organized cervical cancer screening. The claim that self-sampling led to a major improvement of test coverage seems somewhat exaggerated and alternative hypotheses to those provided by the authors on the population who chose self-sampling are possible. Nonetheless, this is a valuable piece of work given the scope of the intervention(s) and the precedent it sets i.e. a crisis can in fact accelerate positive changes in screening that have been academic possibilities rather than practical realities.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  6. Risk of Second Primary Cancers After a Diagnosis of First Primary Cancer: A Pan-Cancer Analysis and Mendelian Randomization Study

    This article has 8 authors:
    1. Xiaohao Ruan
    2. Da Huang
    3. Yongle Zhan
    4. Jingyi Huang
    5. Jinlun Huang
    6. Ada Tsui-Lin NG
    7. James Hok-Leung TSU
    8. Rong Na
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the associations and causal relationship between second primary cancers and the initial diagnosis of a primary cancer via using a large database. The evidence supporting the claims of the authors is solid. The work will be of interest to cancer clinicians.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  7. Identifying metabolic features of colorectal cancer liability using Mendelian randomization

    This article has 22 authors:
    1. Caroline J. Bull
    2. Emma Hazelwood
    3. Joshua A. Bell
    4. Vanessa Y. Tan
    5. Andrei-Emil Constantinescu
    6. Maria Carolina Borges
    7. Danny N. Legge
    8. Kimberly Burrows
    9. Jeroen R. Huyghe
    10. Hermann Brenner
    11. Sergi CastellvĂ­-Bel
    12. Andrew T Chan
    13. Sun-Seog Kweon
    14. Loic Le Marchand
    15. Li Li
    16. Iona Cheng
    17. Rish K. Pai
    18. Jane C. Figueiredo
    19. Neil Murphy
    20. Marc J. Gunter
    21. Nicholas J. Timpson
    22. Emma E. Vincent
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript by Bull et al provides valuable information on the relationship between metabolic features, in particular different lipoproteins and fatty acids, and colorectal cancer. They use solid methods and combine different data sources to analyze forward and reverse Mendelian Randomizations that support their claims.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity
  8. Understanding disruptions in cancer care to reduce increased cancer burden

    This article has 8 authors:
    1. Kia L. Davis
    2. Nicole Ackermann
    3. Lisa M. Klesges
    4. Nora Leahy
    5. Walsh-Bailey Callie
    6. Sarah Humble
    7. Bettina Drake
    8. Vetta L. Sanders Thompson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents patterns of cancer care disruption in southern Illinois and eastern Missouri in the summer of 2020. Survey results show factors that impact cancer care during the COVID-19 pandemic, including group differences by race. The important findings provide solid evidence about variation in cancer care disruptions and opportunities to improve return to care.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  9. Resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication

    This article has 8 authors:
    1. Nora Schmit
    2. Hillary M Topazian
    3. Matteo Pianella
    4. Giovanni D Charles
    5. Peter Winskill
    6. Michael T White
    7. Katharina Hauck
    8. Azra C Ghani
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the optimal prioritization in different malaria transmission settings for the distribution of insecticide-treated nets to reduce the malaria burden. The evidence supporting the claims of the authors is solid. The work will be of interest from a global funder perspective, though somewhat less relevant for individual countries.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 3 listsLatest version Latest activity
  10. Nation-wide mammography screening participation in Denmark during the COVID-19 pandemic: An observational study

    This article has 7 authors:
    1. Tina Bech Olesen
    2. Henry Jensen
    3. Henrik Møller
    4. Jens Winther Jensen
    5. Berit Andersen
    6. Ilse Vejborg
    7. Sisse H. Njor
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This article is of broad interest to public health researchers and to health policymakers in populations with national screening programs. It provides important knowledge on the impact of the COVID-19 pandemic on participation in mammography screening in Denmark by socio-economic indicators. The study provides convincing evidence for how the pandemic exacerbated disparities in breast cancer screening in Denmark.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  11. A Rapid review on the COVID-19 Pandemic’s Global Impact on Breast Cancer Screening Participation Rates and Volumes from January-December 2020

    This article has 6 authors:
    1. Reagan Lee
    2. Wei Xu
    3. Marshall Dozier
    4. Ruth McQuillan
    5. Evropi Theodoratou
    6. Jonine D. Figueroa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents important evidence of the impact of the covid pandemic on breast cancer screening globally but with important variations by healthcare setting. The data analysis is comprehensive, using solid systematic review methods. The results will be of interest to public health policymakers and health care and cancer control practitioners and researchers across the globe.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  12. Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: a cohort study using OpenSAFELY-TPP

    This article has 14 authors:
    1. Agnieszka Lemanska
    2. Colm Andrews
    3. Louis Fisher
    4. Seb Bacon
    5. Adam Frampton
    6. Amir Mehrkar
    7. Peter Inglesby
    8. Simon Davy
    9. Keith J Roberts
    10. Praveetha Patalay
    11. Ben Goldacre
    12. Brian MacKenna
    13. The OpenSAFELY Collaborative
    14. Alex Walker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides useful information on the impact of the pandemic on the quantity of healthcare delivered to patients with pancreatic cancer in England. The authors showed that there was no difference in the number of diagnoses of pancreatic cancer during the pandemic compared to the preceding 5-year period, but a reduction in surgical resections by nearly 25%. They reported no difference in deaths between the two periods. They show no differences in rates of diagnosis, but the clinical relevance is incomplete as they have not compared survival from cancer between those time periods.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  13. Sleep Regularity and Mortality: A Prospective Analysis in the UK Biobank

    This article has 7 authors:
    1. Lachlan Cribb
    2. Ramon Sha
    3. Stephanie Yiallourou
    4. Natalie A Grima
    5. Marina Cavuoto
    6. Andree-Ann Baril
    7. Matthew P. Pase
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript provides fundamental findings on the association between sleep regularity and mortality in the UK Biobank, which is a popular topic in recent sleep and circadian research in population-based studies. The study is based on a large accelerometer study with validated follow-up of incident diseases and deaths, and the data quality and large sample size are convincing and strengthen the credibility of the conclusion. This will be of wide interest to researchers in the sleep study field, epidemiologists, practicing clinicians and the general public.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
  14. Global diversity and antimicrobial resistance of typhoid fever pathogens: insights from 13,000 Salmonella Typhi genomes

    This article has 113 authors:
    1. Megan E. Carey
    2. Zoe A. Dyson
    3. Danielle J. Ingle
    4. Afreenish Amir
    5. Mabel K. Aworh
    6. Marie Anne Chattaway
    7. Ka Lip Chew
    8. John A. Crump
    9. Nicholas A. Feasey
    10. Benjamin P. Howden
    11. Karen H. Keddy
    12. Mailis Maes
    13. Christopher M. Parry
    14. Sandra Van Puyvelde
    15. Hattie E. Webb
    16. Ayorinde O. Afolayan
    17. Shalini Anandan
    18. Jason R. Andrews
    19. Philip M. Ashton
    20. Buddha Basnyat
    21. Ashish Bavdekar
    22. Isaac I. Bogoch
    23. John D. Clemens
    24. Kesia E. da Silva
    25. Anuradha De
    26. Joep de Ligt
    27. Paula Lucia Diaz Guevara
    28. Christiane Dolecek
    29. Shanta Dutta
    30. Louise Francois Watkins
    31. Denise O. Garrett
    32. Gauri Godbole
    33. Melita A. Gordon
    34. Andrew R. Greenhill
    35. Chelsey Griffin
    36. Madhu Gupta
    37. Rene Hendricksen
    38. Robert S. Heyderman
    39. Yogesh Hooda
    40. Juan Carlos Hormazabal
    41. Odion O. Ikhimiukor
    42. Junaid Iqbal
    43. Jobin J. Jacob
    44. Claire Jenkins
    45. Dasaratha Ramaiah Jinka
    46. Jacob John
    47. Gagandeep Kang
    48. Abdoulie Kanteh
    49. Arti Kapil
    50. Abhilasha Karkey
    51. Samuel Kariuki
    52. Robert A. Kingsley
    53. Roshine Mary Koshy
    54. A. C. Lauer
    55. Myron M. Levine
    56. Ravikumar Kadahalli Lingegowda
    57. Stephen P. Luby
    58. Grant A. Mackenzie
    59. Tapfumanei A. Mashe
    60. Chisomo Msefula
    61. Ankur Mutreja
    62. Geetha Nagaraj
    63. Savitha Nagaraj
    64. Satheesh Nair
    65. Take K. Naseri
    66. Susana Nimarota-Brown
    67. Elisabeth Njamkepo
    68. Iruka N. Okeke
    69. Sulochana Putli Bai Perumal
    70. Andrew J. Pollard
    71. Agila Kumari Pragasam
    72. Firdausi Qadri
    73. Farah N. Qamar
    74. Sadia Isfat Ara Rahman
    75. Savitra D. Rambocus
    76. David A. Rasko
    77. Pallab Ray
    78. Roy Robins-Browne
    79. Temsunaro Rongsen-Chandola
    80. Jean Pierre Rutanga
    81. Samir K. Saha
    82. Senjuti Saha
    83. Karnika Saigal
    84. Mohammad Saiful Islam Sajib
    85. Jessica C. Seidman
    86. Jivan Shakya
    87. Varun Shamanna
    88. Jayanthi Shastri
    89. Rajeev Shrestha
    90. Sonia Sia
    91. Michael J. Sikorski
    92. Ashita Singh
    93. Anthony M. Smith
    94. Kaitlin A. Tagg
    95. Dipesh Tamrakar
    96. Arif Mohammad Tanmoy
    97. Maria Thomas
    98. Mathew S. Thomas
    99. Robert Thomsen
    100. Nicholas R. Thomson
    101. Siaosi Tupua
    102. Krista Vaidya
    103. Mary Valcanis
    104. Balaji Veeraraghavan
    105. François-Xavier Weill
    106. Jackie Wright
    107. Gordon Dougan
    108. Silvia ArgimĂłn
    109. Jacqueline A. Keane
    110. David M. Aanensen
    111. Stephen Baker
    112. Kathryn E. Holt
    113. Global Typhoid Genomics Consortium Group Authorship
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Although largely descriptive, this meta-analysis of 13,000 published Typhi genomes is hugely important to public health. The dataset and presented analysis represents the first wholesale analysis of all available Typhi genomes from the last 21 years. The findings are of great significance to tracking the emergence and maintenance of AMR in Typhi and include novel insights into XDR strain emergence in Pakistan as well as the relationship between MDR maintenance and chromosomal integration.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  15. The Impact of COVID-19 on Cancer Screening and Treatment in Older Adults: The Multiethnic Cohort Study

    This article has 6 authors:
    1. Victoria P. Mak
    2. Kami White
    3. Lynne R. Wilkens
    4. Iona Cheng
    5. Christopher Haiman
    6. LoĂŻc Le Marchand
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors used the Multiethnic Cohort (MEC) study to study how COVID-19 impacted access to cancer screenings and treatment. This study's important findings served to identify key factors associated with cancer-related screening and healthcare-seeking during the pandemic. This investigation provides solid evidence to inform future policies, particularly in older and vulnerable populations.

    Reviewed by eLife

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  16. Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

    This article has 20 authors:
    1. Oliver Robinson
    2. ChungHo Lau
    3. Sungyeon Joo
    4. Sandra Andrusaityte
    5. Eva BorrĂ s
    6. Paula de Prado-Bert
    7. Lida Chatzi
    8. Hector C. Keun
    9. Regina Grazuleviciene
    10. Kristine B. GĂĽtzkow
    11. LĂ©a Maitre
    12. Dries S. Martens
    13. Eduard Sabido
    14. Valérie Siroux
    15. Jose Urquiza
    16. Marina Vafeiadi
    17. John Wright
    18. Tim Nawrot
    19. Mariona Bustamante
    20. Martine Vrijheid
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important study that examined multiple biological age measures in children, which has been lacking in literature. The findings of this study provided convincing evidence to interpret and understand the aging and developmental processes in children.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  17. Building resilient cervical cancer prevention through gender-neutral HPV vaccination

    This article has 5 authors:
    1. Irene Man
    2. Damien Georges
    3. Rengaswamy Sankaranarayanan
    4. Partha Basu
    5. Iacopo Baussano
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings on how gender-neutral vaccination against human papillomavirus can help improve program resilience in the case of vaccination disruptions. The evidence supporting the claims of the authors is convincing, although the results are only applicable to India and other countries with a similar HPV context; researchers can adapt the model for their local context and use it as a starting point for future research.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  18. Quantification of impact of COVID-19 pandemic on cancer screening programmes -a case study from Argentina, Bangladesh, Colombia, Morocco, Sri Lanka and Thailand

    This article has 11 authors:
    1. Eric Lucas
    2. Raul Murillo
    3. Silvina Arrossi
    4. Martin Bárcena
    5. Youssef Chami
    6. Ashrafun Nessa
    7. Suraj Perera
    8. J Padmaka Silva
    9. Suleeporn Sangrajrang
    10. Richard Muwonge
    11. Partha Basu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides important estimates from international cancer screening data repository about the impact of the COVID-pandemic related disruptions on cancer screening programs in selected low- and middle-income countries. The evidence supporting the study is solid and relies on national-level screening program attendee volumes and assessments of screen positives during 2019 (pre-pandemic) and 2020 (during the pandemic). The study provides real-world data estimates of proportions/volumes of missed screenings due to pandemic control measures (lockdowns and closures) and may contribute to future modelling efforts for measuring the impact on late/advanced stage detection and excess case burden and mortality.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  19. Social isolation is linked to declining grey matter structure and cognitive functions in the LIFE-Adult panel study

    This article has 11 authors:
    1. Laurenz Lammer
    2. Frauke Beyer
    3. Melanie Luppa
    4. Christian Sander
    5. Ronny Baber
    6. Christoph Engel
    7. Kerstin Wirkner
    8. Markus Loeffler
    9. Steffi G Riedel-Heller
    10. Arno Villringer
    11. Veronica Witte
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides an important demonstration that loneliness is associated with smaller hippocampal volume, reduced cortical thickness, and worse cognition in healthy older adults. This has theoretical or practical implications beyond a single subfield. The strength of evidence is solid given the cross-sectional and longitudinal design with a few weaknesses. With the analytical and interpretational part strengthened, this paper would be of interest to gerontologists, and dementia/cognitive aging researchers.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  20. Hierarchical machine learning predicts geographical origin of Salmonella within four minutes of sequencing

    This article has 6 authors:
    1. Sion C. Bayliss
    2. Rebecca K. Locke
    3. Claire Jenkins
    4. Marie Anne Chattaway
    5. Timothy J. Dallman
    6. Lauren A. Cowley
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents a machine learning-based classifier that can accurately determine the geographic origin of a Salmonella enterica sample from its whole-genome sequencing data in under five minutes leading to actionable public health insights. Applying the method to 2,313 whole genome sequences collected in the United Kingdom and several external validation datasets, the authors provide convincing evidence that Salmonella genomic data can be used to identify the likely geographic source of a food-borne outbreak and, in most cases, correctly identify the country of origin of an infection acquired overseas. The work presents an excellent case for the potential utility of routine genomics coupled with machine learning for public health microbiology and the methods are likely to be applicable to other pathogens besides Salmonella enterica.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity