Examining the Role of Extrachromosomal DNA in 1,216 Lung Cancers
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The role of extrachromosomal DNA (ecDNA) in lung cancer, particularly in subjects who never smoked (LCINS), remains unclear. Examination of 1,216 whole-genome-sequenced lung cancers identified ecDNA in 18.9% of patients. Enrichment of MDM2 and other oncogenes amplification via ecDNA possibly drives a LCINS subset. Tumors harboring ecDNA or other focal amplifications showed similarly poor survival. A strong association with whole-genome doubling suggests most ecDNA reflects genomic instability in treatment-naive lung cancer.
