Evaluated articles

Targeting protein-ligand neosurfaces using a generalizable deep learning approach

1. Anthony Marchand
2. Stephen Buckley
3. Arne Schneuing
4. Martin Pacesa
5. Pablo Gainza
6. Evgenia Elizarova
7. Rebecca M. Neeser
8. Pao-Wan Lee
9. Luc Reymond
10. Maddalena Elia
11. Leo Scheller
12. Sandrine Georgeon
13. Joseph Schmidt
14. Philippe Schwaller
15. Sebastian J. Maerkl
16. Michael Bronstein
17. Bruno E. Correia

Reviewed by PREreview

Active mechanics of sea star oocytes

1. Peter J. Foster
2. Sebastian Fürthauer
3. Nikta Fakhri

Reviewed by PREreview

A fungal transcription factor BOT6 facilitates the transition of a beneficial root fungus into an adapted anthracnose pathogen

1. Ren Ujimatsu
2. Junya Takino
3. Masami Nakamura
4. Hiromi Haba
5. Atsushi Minami
6. Kei Hiruma

Reviewed by PREreview

Divergent mechanisms of steroid inhibition in the human ρ1 GABA _A receptor

1. Chen Fan
2. John Cowgill
3. Rebecca J. Howard
4. Erik Lindahl

Reviewed by PREreview

Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function

1. Magdalena Topolska
2. Antoni Beltran
3. Ben Lehner

Reviewed by PREreview

Mutational Profiling of SARS-CoV-2 PLpro in human cells reveals requirements for function, structure, and drug escape

1. Xinyu Wu
2. Margareta Go
3. Julie V. Nguyen
4. Nathan W. Kuchel
5. Bernadine G.C. Lu
6. Kym N. Lowes
7. Dale J. Calleja
8. Jeffrey P. Mitchell
9. Guillaume Lessene
10. David Komander
11. Matthew E. Call
12. Melissa J. Call

Reviewed by PREreview

High-throughput computational discovery of inhibitory protein fragments with AlphaFold

1. Andrew Savinov
2. Sebastian Swanson
3. Amy E. Keating
4. Gene-Wei Li

Reviewed by PREreview

Graft incompatibility between pepper and tomato can be attributed to genetic incompatibility between diverged immune systems

1. Hannah Rae Thomas
2. Alice Gevorgyan
3. Alexandra Hermanson
4. Samantha Yanders
5. Lindsay Erndwein
6. Matthew Norman-Ariztía
7. Erin E. Sparks
8. Margaret H Frank

Reviewed by PREreview

Assessing the Incidence of Postoperative Diabetes in Gastric Cancer Patients: A Comparative Study of Roux-en-Y Gastrectomy and Other Surgical Reconstruction Techniques

1. Tatsuki Onishi

Reviewed by PREreview

INAEME: Integral Neoantigen Analysis with Entirety of Mutational Events

1. Vladimir Kovacevic
2. Ognjen S. Milicevic
3. Nevena M. Ilic Raicevic
4. Milica Kojicic
5. Ana Mijalkovic Lazic
6. Nikola Skundric
7. Jack DiGiovanna

Reviewed by PREreview

Does early-stage Alzheimer’s disease affect the dynamics of motor adaptation?

1. K Sutter
2. Wijdenes L Oostwoud
3. RJ van Beers
4. JAHR Claassen
5. RPC Kessels
6. WP Medendorp

Reviewed by PREreview

Prediction of Ca ²⁺ binding site in proteins with a fast and accurate method based on statistical mechanics and analysis of crystal structures

1. Abdul Basit
2. Devapriya Choudhury
3. Pradipta Bandyopadhyay

Reviewed by PREreview

Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress

1. Showkat A. Dar
2. Sulochan Malla
3. Vlastimil Martinek
4. Matthew J. Payea
5. Christopher T. Lee
6. Jessica Martin
7. Aditya J. Khandeshi
8. Jennifer L. Martindale
9. Cedric Belair
10. Manolis Maragkakis

• Curated by eLife

  eLife assessment

  This valuable study describes mRNA shortening during cellular stress and interestingly observes that this shortening is dependent on localization in stress granules. Surprisingly, this mRNA shortening does not appear to require the shortening of polyA tails. These are in principle novel findings, but the evidence for them is currently incomplete. Additional experiments would help bolster confidence in how the authors interpret their data.

Reviewed by PREreview, eLife

Modular small RNA drives pathogen emergence

1. Deepak Balasubramanian
2. Salvador Almagro-Moreno

Reviewed by PREreview

More than a token photo: humanizing scientists enhances student engagement

1. Robin A. Costello
2. Emily P. Driessen
3. Melissa K. Kjelvik
4. Elizabeth H. Schultheis
5. Rachel M. Youngblood
6. Ash T. Zemenick
7. Marjorie G. Weber
8. Cissy J. Ballen

Reviewed by PREreview

Metric Ion Classification (MIC): A deep learning tool for assigning ions and waters in cryo-EM and x-ray crystallography structures

1. Laura Shub
2. Wenjin Liu
3. Georgios Skiniotis
4. Michael J. Keiser
5. Michael J. Robertson

Reviewed by PREreview

Global diversity and evolution of Salmonella Panama, an understudied serovar causing gastrointestinal and invasive disease worldwide: a genomic epidemiology study

1. Caisey V. Pulford
2. Blanca M. Perez-Sepulveda
3. Danielle J. Ingle
4. Rebecca J. Bengtsson
5. Rebecca J. Bennett
6. Ella V. Rodwell
7. Maria Pardos de la Gandara
8. Charlotte Chong
9. P. Malaka De Silva
10. Magali Ravel
11. Véronique Guibert
12. Elisabeth Njamkepo
13. Neil Hall
14. Marie A. Chattaway
15. Benjamin P. Howden
16. Deborah A Williamson
17. Jay C. D. Hinton
18. François-Xavier Weill
19. Kate S. Baker

Reviewed by PREreview

Giant genes are rare but implicated in cell wall degradation by predatory bacteria

1. Jacob West-Roberts
2. Luis Valentin-Alvarado
3. Susan Mullen
4. Rohan Sachdeva
5. Justin Smith
6. Laura A. Hug
7. Daniel S. Gregoire
8. Wentso Liu
9. Tzu-Yu Lin
10. Gabriel Husain
11. Yuki Amano
12. Lynn Ly
13. Jillian F. Banfield

Reviewed by PREreview