Latest preprint reviews

1. Inhibition of ULK1/2 and KRAS ^G12C controls tumor growth in preclinical models of lung cancer

   This article has 13 authors:

   1. Phaedra C. Ghazi
   2. Kayla T. O’Toole
   3. Sanjana Srinivas Boggaram
   4. Michael T. Scherzer
   5. Mark R. Silvis
   6. Yun Zhang
   7. Madhumita Bogdan
   8. Bryan D. Smith
   9. Guillermina Lozano
   10. Daniel L. Flynn
   11. Eric L. Snyder
   12. Conan G. Kinsey
   13. Martin McMahon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a mechanistic study showing the effect of combining inhibition of autophagy (through ULK1/2) and KRAS (using sotorasib) on KRAS mutant NSCLC making the study valuable to cancer biologists and more broadly in a clinical setting. The evidence generated by GEM mouse models and cell lines is solid but could be further strengthened by increasing the mouse cohort size. This study holds translational relevance beyond NSCLC to other indications that carry KRAS mutations.

   Reviewed by eLife

2. An Evaluation of the Tumor Microenvironment through CALR, IL1R1, IFNB1, and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients

   This article has 12 authors:

   1. Lilong Liu
   2. Zhenghao Liu
   3. Lei Fan
   4. Zhipeng Yao
   5. Junyi Hu
   6. Yaxin Hou
   7. Yang Li
   8. Yuhong Ding
   9. Yingchun Kuang
   10. Ke Chen
   11. Yi Hao
   12. Zheng Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study investigates the associations of four ICD-related genes in bladder cancer with increased immune cell infiltration and more prolonged survival. The study is valuable because it identifies a risk-scoring model, showing a correlation between high-risk scores based on four ICD-related genes and weak anti-tumour immune function. However, the evidence supporting the association of these genes and immunotherapy response is incomplete.

   Reviewed by eLife

3. Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

   This article has 7 authors:

   1. Kyle Spinler
   2. Michael Hamilton
   3. Jeevisha Bajaj
   4. Yutaka Shima
   5. Emily Diaz
   6. Marcie Kritzik
   7. Tannishtha Reya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents important findings on the role of MSI2-HOXA9 translocation in chronic myeloid leukemia. The authors provide convincing evidence supporting the role of this translocation in leukemogenesis by using elegant mouse modeling and in vitro mechanistic studies. Consistent with the reviews, the studies can be strengthened with further murine and cell line experiments.

   Reviewed by eLife

4. Drosophila epidermal cells are intrinsically mechanosensitive and drive nociceptive behavioral outputs

   This article has 15 authors:

   1. Jiro Yoshino
   2. Sonali S. Mali
   3. Claire R. Williams
   4. Takeshi Morita
   5. Chloe E. Emerson
   6. Christopher J. Arp
   7. Sophie E. Miller
   8. Chang Yin
   9. Lydia Thé
   10. Chikayo Hemmi
   11. Mana Motoyoshi
   12. Kenichi Ishii
   13. Kazuo Emoto
   14. Diana M. Bautista
   15. Jay Z. Parrish

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important work and provides a significant advance in our understanding of mechanosensation in the epidermis. The evidence presented is solid, however, additional work such as testing whether the activation time can be shorter, addressing the mechanism underlying endoplasmic reticulum calcium release, and improving the clarity of writing and rigor of analysis would strengthen the study. This work will be of broad interest to neurobiologists, epithelial cell biologists, and mechanobiologists.

   Reviewed by eLife, Arcadia Science

5. Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

   This article has 15 authors:

   1. Alessandra M. Araujo
   2. Joseph D. Dekker
   3. Kendra Garrison
   4. Zhe Su
   5. Catherine Rhee
   6. Zicheng Hu
   7. Bum-Kyu Lee
   8. Daniel Osorio Hurtado
   9. Jiwon Lee
   10. Vishwanath R. Iyer
   11. Lauren I. R. Ehrlich
   12. George Georgiou
   13. Gregory C. Ippolito
   14. S. Stephen Yi
   15. Haley O. Tucker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study aims to add fresh insights into the sharing of lymphoid and CDP (common DC precursor) lineage origin of plasmacytoid dendritic cells (pDCs). The evidence for a small subset of pDCs sharing its origin with B cell progenitors and depending on BCL11a expression is solid, although further functional characterization of the reported pDC subset would significantly enhance the significance of the study. The study will be of relevance to cellular immunologists interested in the ontogeny of plasmacytoid dendritic cells.

   Reviewed by eLife

6. Fine-scale tracking reveals visual field use for predator detection and escape in collective foraging of pigeon flocks

   This article has 2 authors:

   1. Mathilde Delacoux
   2. Fumihiro Kano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this fundamental study, the authors use innovative fine-scale motion capture technologies to study visual vigilance with high-acuity vision, to estimate the visual fixation of free-feeding pigeons. The authors present convincing evidence for use of the fovea to inspect predator cues, the behavioral state influencing the latency for fovea use, and the use of the fovea decreasing the latency to escape of both the focal individual and other flock members. The work will be of broad interest to behavioral ecologists.

   Reviewed by eLife

7. SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

   This article has 12 authors:

   1. Somen K Mistri
   2. Brianna M. Hilton
   3. Katherine J. Horrigan
   4. Emma S. Andretta
   5. Remi Savard
   6. Oliver Dienz
   7. Kenneth J Hampel
   8. Diana L. Gerrard
   9. Joshua T. Rose
   10. Nikoletta Sidiropoulos
   11. Devdoot Majumdar
   12. Jonathan E. Boyson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study highlights the role of SLAM-SAP signaling in shaping innate-like γδ T cell subsets, providing compelling evidence for the importance of SLAM-SAP in immune system regulation, and the potential implications of the findings for tumor surveillance and infectious disease management. The work will be of broad interest to immunologists.

   Reviewed by eLife

8. Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

   This article has 3 authors:

   1. Suman Kundu
   2. Advait Shetty
   3. Maria Gomes-Solecki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study could potential provide insight into mechanisms for vaccine-mediated protection, although the evidence for live Leptospira contributing to protection against a pathogenic serovar is still incomplete. The work will be of interest to the scientists interested in host-pathogen interactions and leptospirosis.

   Reviewed by eLife

9. Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

   This article has 9 authors:

   1. Jarno Mäkelä
   2. Alexandros Papagiannakis
   3. Wei-Hsiang Lin
   4. Michael C. Lanz
   5. Skye Glenn
   6. Matthew Swaffer
   7. Georgi K. Marinov
   8. Jan M. Skotheim
   9. Christine Jacobs-Wagner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study represents a fundamental contribution to our understanding of how gene expression levels are controlled in bacteria. Through a series of compelling and careful experiments, relying on a mutant that blocks DNA replication but permits growth, and using various methods, the authors reveal how genome concentration rapidly becomes limiting for growth when replication is inhibited. This work contributes to our understanding of the contributions and limiting roles of DNA, mRNA, and ribosomes for growth in bacteria, and will be of considerable interest within both systems biology and microbial physiology.

   Reviewed by eLife

10. The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

    This article has 10 authors:

    1. Nasim Saadat
    2. Rhys N. Colson
    3. Acadia L. Grimme
    4. Uri Seroussi
    5. Joshua W. Anderson
    6. Julie M. Claycomb
    7. Matthew C. J. Wilce
    8. Katherine McJunkin
    9. Jacqueline A. Wilce
    10. Peter R. Boag

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This useful study identifies amino acid residues in the C. elegans RNA-binding protein NHL-2 that are required for RNA binding in vitro and NHL-2 function in vivo. The evidence in support of the authors' mechanistic model is currently incomplete, as data implicating specific NHL-2 amino acids in RNA binding per se in vivo are not presented. This manuscript will be of interest to scientists working in the area of gene regulation.

    Reviewed by eLife