Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank
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SciScore for 10.1101/2020.07.09.20149369: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Stratified analyses were conducted according to the median age at infection (<70, ≥70 years), sex (male, female), BMI (<30, ≥30 kg/m2), physical activity (≤median, >median), and smoking status (never, ever) in the fully-adjusted model. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Severa…
SciScore for 10.1101/2020.07.09.20149369: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Stratified analyses were conducted according to the median age at infection (<70, ≥70 years), sex (male, female), BMI (<30, ≥30 kg/m2), physical activity (≤median, >median), and smoking status (never, ever) in the fully-adjusted model. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Several potential limitations also need to be acknowledged. First, the observational nature of this study prevents us from inferring causality. However, our sensitivity analyses excluding baseline CVD and cancer supported the robustness of the findings. Second, given the lack of repeated IGF-1 measurements, we were unable to analyze the relationship between dynamic IGF-1 concentrations and COVID-19 mortality. However, we calculated the intraclass correlation coefficient (ICC) between IGF1 measurements collected 4 years apart in a subcohort (n= 16,356). The ICC value of 0.78, consistent with the previous data 19, indicates that IGF1 levels are generally stable over time. Third, due to limited coverage of coronavirus testing in the UK, ascertainment bias cannot be avoided. In addition, UK Biobank is not a representative sample of the UK population 20, limiting ability to generalize the results to the whole UK or other populations.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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